FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967661330> ?p ?o ?g. }

• W1967661330 endingPage "918" @default.
• W1967661330 startingPage "911" @default.
• W1967661330 abstract "Notch signaling is shown to regulate the browning of adipocytes and whole-body energy expenditure, with inhibition leading to protection from diet-induced obesity in mice. Beige adipocytes in white adipose tissue (WAT) are similar to classical brown adipocytes in that they can burn lipids to produce heat. Thus, an increase in beige adipocyte content in WAT browning would raise energy expenditure and reduce adiposity. Here we report that adipose-specific inactivation of Notch1 or its signaling mediator Rbpj in mice results in browning of WAT and elevated expression of uncoupling protein 1 (Ucp1), a key regulator of thermogenesis. Consequently, as compared to wild-type mice, Notch mutants exhibit elevated energy expenditure, better glucose tolerance and improved insulin sensitivity and are more resistant to high fat diet–induced obesity. By contrast, adipose-specific activation of Notch1 leads to the opposite phenotypes. At the molecular level, constitutive activation of Notch signaling inhibits, whereas Notch inhibition induces, Ppargc1a and Prdm16 transcription in white adipocytes. Notably, pharmacological inhibition of Notch signaling in obese mice ameliorates obesity, reduces blood glucose and increases Ucp1 expression in white fat. Therefore, Notch signaling may be therapeutically targeted to treat obesity and type 2 diabetes." @default.
• W1967661330 created "2016-06-24" @default.
• W1967661330 creator A5051704299 @default.
• W1967661330 creator A5058508346 @default.
• W1967661330 creator A5061594246 @default.
• W1967661330 creator A5063871472 @default.
• W1967661330 creator A5067551696 @default.
• W1967661330 creator A5068252474 @default.
• W1967661330 creator A5069121438 @default.
• W1967661330 creator A5075465842 @default.
• W1967661330 creator A5079013323 @default.
• W1967661330 creator A5081900779 @default.
• W1967661330 creator A5082836130 @default.
• W1967661330 date "2014-07-20" @default.
• W1967661330 modified "2023-10-11" @default.
• W1967661330 title "Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity" @default.
• W1967661330 cites W1503830687 @default.
• W1967661330 cites W1591773525 @default.
• W1967661330 cites W1660631781 @default.
• W1967661330 cites W1964873147 @default.
• W1967661330 cites W1965079305 @default.
• W1967661330 cites W1969239687 @default.
• W1967661330 cites W1977962361 @default.
• W1967661330 cites W1978586367 @default.
• W1967661330 cites W1984759538 @default.
• W1967661330 cites W1985086027 @default.
• W1967661330 cites W1993677020 @default.
• W1967661330 cites W1993987541 @default.
• W1967661330 cites W1995810876 @default.
• W1967661330 cites W2004861205 @default.
• W1967661330 cites W2005827500 @default.
• W1967661330 cites W2006547120 @default.
• W1967661330 cites W2006717309 @default.
• W1967661330 cites W2007715079 @default.
• W1967661330 cites W2013891116 @default.
• W1967661330 cites W2013900763 @default.
• W1967661330 cites W2014426248 @default.
• W1967661330 cites W2016108853 @default.
• W1967661330 cites W2027753197 @default.
• W1967661330 cites W2035241082 @default.
• W1967661330 cites W2036378283 @default.
• W1967661330 cites W2039382168 @default.
• W1967661330 cites W2040328785 @default.
• W1967661330 cites W2044021940 @default.
• W1967661330 cites W2053056402 @default.
• W1967661330 cites W2055928731 @default.
• W1967661330 cites W2058733797 @default.
• W1967661330 cites W2062600479 @default.
• W1967661330 cites W2064433079 @default.
• W1967661330 cites W2066255742 @default.
• W1967661330 cites W2068462949 @default.
• W1967661330 cites W2070081201 @default.
• W1967661330 cites W2071631797 @default.
• W1967661330 cites W2073578382 @default.
• W1967661330 cites W2077164150 @default.
• W1967661330 cites W2083602312 @default.
• W1967661330 cites W2087524781 @default.
• W1967661330 cites W2088986234 @default.
• W1967661330 cites W2089025864 @default.
• W1967661330 cites W2090773805 @default.
• W1967661330 cites W2096388724 @default.
• W1967661330 cites W2103370215 @default.
• W1967661330 cites W2112076976 @default.
• W1967661330 cites W2115313813 @default.
• W1967661330 cites W2118055379 @default.
• W1967661330 cites W2124205424 @default.
• W1967661330 cites W2142653769 @default.
• W1967661330 cites W2145109396 @default.
• W1967661330 cites W2145142659 @default.
• W1967661330 cites W2145639699 @default.
• W1967661330 cites W2146625096 @default.
• W1967661330 cites W2148400263 @default.
• W1967661330 cites W2149557024 @default.
• W1967661330 cites W2151064573 @default.
• W1967661330 cites W2151470490 @default.
• W1967661330 cites W2154144191 @default.
• W1967661330 cites W2156894557 @default.
• W1967661330 cites W2163748946 @default.
• W1967661330 cites W2167362732 @default.
• W1967661330 cites W2168647623 @default.
• W1967661330 cites W2169781001 @default.
• W1967661330 cites W2169845602 @default.
• W1967661330 cites W2409440302 @default.
• W1967661330 cites W4249727000 @default.
• W1967661330 doi "https://doi.org/10.1038/nm.3615" @default.
• W1967661330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4181850" @default.
• W1967661330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25038826" @default.
• W1967661330 hasPublicationYear "2014" @default.
• W1967661330 type Work @default.
• W1967661330 sameAs 1967661330 @default.
• W1967661330 citedByCount "200" @default.
• W1967661330 countsByYear W19676613302014 @default.
• W1967661330 countsByYear W19676613302015 @default.
• W1967661330 countsByYear W19676613302016 @default.
• W1967661330 countsByYear W19676613302017 @default.
• W1967661330 countsByYear W19676613302018 @default.
• W1967661330 countsByYear W19676613302019 @default.
• W1967661330 countsByYear W19676613302020 @default.

• next