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• W1967674458 abstract "TACT is an National Institutes of Health-sponsored, randomized, double-blind, placebo-controlled, 2 × 2 factorial clinical trial testing the benefits and risks of 40 infusions of a multicomponent disodium EDTA chelation solution compared with placebo and of an oral, high-dose multivitamin and mineral supplement. TACT has randomized and will follow up 1,708 patients for an average of approximately 4 years. The primary end point is a composite of all-cause mortality, myocardial infarction, stroke, coronary revascularization, and hospitalization for angina. A 900-patient substudy will examine quality-of-life outcomes. The trial is designed to have >85% power to detect a 25% relative reduction in the primary end point for each treatment factor. Enrollment began in September 2003 and was completed in October 2010." @default.
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• W1967674458 date "2012-01-01" @default.
• W1967674458 modified "2023-09-26" @default.
• W1967674458 title "Design of the Trial to Assess Chelation Therapy (TACT)" @default.
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• W1967674458 doi "https://doi.org/10.1016/j.ahj.2011.10.002" @default.
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