FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967676683> ?p ?o ?g. }

• W1967676683 endingPage "343" @default.
• W1967676683 startingPage "330" @default.
• W1967676683 abstract "At least seven distinct epidermal growth factor (EGF) ligands bind to and activate the EGF receptor (EGFR). This activation plays an important role in the embryo and in the maintenance of adult tissues. Importantly, pharmacologic EGFR inhibition also plays a critical role in the pathophysiology of diverse disease states, especially cancer. The roles of specific EGFR ligands are poorly defined in these disease states. Accumulating evidence suggests a role for transforming growth factor <i>α</i> (TGF<i>α</i>) in skin, lung, and kidney disease. To explore the role of Tgfa, we generated a monoclonal antibody (mAb41) that binds to and neutralizes human Tgfa with high affinity (<i>K</i>_D = 36.5 pM). The antibody also binds human epiregulin (Ereg) (<i>K</i>_D = 346.6 pM) and inhibits ligand induced myofibroblast cell proliferation (IC₅₀ values of 0.52 and 1.12 nM for human Tgfa and Ereg, respectively). In vivo, a single administration of the antibody to pregnant mice (30 mg/kg s.c. at day 14 after plug) or weekly administration to neonate mice (20 mg/kg s.c. for 4 weeks) phenocopy <i>Tgfa</i> knockout mice with curly whiskers, stunted growth, and expansion of the hypertrophic zone of growth plate cartilage. Humanization of this monoclonal antibody to a human IgG4 antibody (LY3016859) enables clinical development. Importantly, administration of the humanized antibody to cynomolgus monkeys is absent of the skin toxicity observed with current EGFR inhibitors used clinically and no other pathologies were noted, indicating that neutralization of Tgfa could provide a relatively safe profile as it advances in clinical development." @default.
• W1967676683 created "2016-06-24" @default.
• W1967676683 creator A5004789055 @default.
• W1967676683 creator A5013156518 @default.
• W1967676683 creator A5022802346 @default.
• W1967676683 creator A5046986458 @default.
• W1967676683 creator A5047159128 @default.
• W1967676683 creator A5047229428 @default.
• W1967676683 creator A5054949108 @default.
• W1967676683 creator A5057773812 @default.
• W1967676683 creator A5058150471 @default.
• W1967676683 creator A5060445702 @default.
• W1967676683 creator A5062912509 @default.
• W1967676683 creator A5066230672 @default.
• W1967676683 creator A5070073175 @default.
• W1967676683 creator A5071722069 @default.
• W1967676683 date "2014-02-11" @default.
• W1967676683 modified "2023-09-26" @default.
• W1967676683 title "Generation and Activity of a Humanized Monoclonal Antibody That Selectively Neutralizes the Epidermal Growth Factor Receptor Ligands Transforming Growth Factor-<i>α</i>and Epiregulin" @default.
• W1967676683 cites W1548966243 @default.
• W1967676683 cites W1595575599 @default.
• W1967676683 cites W1704710159 @default.
• W1967676683 cites W1945644751 @default.
• W1967676683 cites W1963529390 @default.
• W1967676683 cites W1964321121 @default.
• W1967676683 cites W1966658428 @default.
• W1967676683 cites W1972036696 @default.
• W1967676683 cites W1981493299 @default.
• W1967676683 cites W1982653300 @default.
• W1967676683 cites W1985304386 @default.
• W1967676683 cites W1986746869 @default.
• W1967676683 cites W1992665949 @default.
• W1967676683 cites W1992913621 @default.
• W1967676683 cites W1993931106 @default.
• W1967676683 cites W1999639028 @default.
• W1967676683 cites W2007649418 @default.
• W1967676683 cites W2007707703 @default.
• W1967676683 cites W2017751932 @default.
• W1967676683 cites W2022406746 @default.
• W1967676683 cites W2030005349 @default.
• W1967676683 cites W2031520822 @default.
• W1967676683 cites W2049099038 @default.
• W1967676683 cites W2057044649 @default.
• W1967676683 cites W2059858274 @default.
• W1967676683 cites W2061517375 @default.
• W1967676683 cites W2068480689 @default.
• W1967676683 cites W2073738021 @default.
• W1967676683 cites W2074142082 @default.
• W1967676683 cites W2076243351 @default.
• W1967676683 cites W2084824122 @default.
• W1967676683 cites W2087585030 @default.
• W1967676683 cites W2088370531 @default.
• W1967676683 cites W2097097666 @default.
• W1967676683 cites W2098378575 @default.
• W1967676683 cites W2099583536 @default.
• W1967676683 cites W2102554866 @default.
• W1967676683 cites W2109642121 @default.
• W1967676683 cites W2116406150 @default.
• W1967676683 cites W2117939120 @default.
• W1967676683 cites W2132650643 @default.
• W1967676683 cites W2132782966 @default.
• W1967676683 cites W2133520792 @default.
• W1967676683 cites W2134533989 @default.
• W1967676683 cites W2137033699 @default.
• W1967676683 cites W2137584473 @default.
• W1967676683 cites W2142555112 @default.
• W1967676683 cites W2143708659 @default.
• W1967676683 cites W2144590322 @default.
• W1967676683 cites W2145201731 @default.
• W1967676683 cites W2167781127 @default.
• W1967676683 cites W2181958706 @default.
• W1967676683 cites W2218760274 @default.
• W1967676683 cites W2323517468 @default.
• W1967676683 cites W4232995978 @default.
• W1967676683 doi "https://doi.org/10.1124/jpet.113.210765" @default.
• W1967676683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24518034" @default.
• W1967676683 hasPublicationYear "2014" @default.
• W1967676683 type Work @default.
• W1967676683 sameAs 1967676683 @default.
• W1967676683 citedByCount "12" @default.
• W1967676683 countsByYear W19676766832014 @default.
• W1967676683 countsByYear W19676766832015 @default.
• W1967676683 countsByYear W19676766832016 @default.
• W1967676683 countsByYear W19676766832017 @default.
• W1967676683 countsByYear W19676766832018 @default.
• W1967676683 countsByYear W19676766832020 @default.
• W1967676683 countsByYear W19676766832021 @default.
• W1967676683 crossrefType "journal-article" @default.
• W1967676683 hasAuthorship W1967676683A5004789055 @default.
• W1967676683 hasAuthorship W1967676683A5013156518 @default.
• W1967676683 hasAuthorship W1967676683A5022802346 @default.
• W1967676683 hasAuthorship W1967676683A5046986458 @default.
• W1967676683 hasAuthorship W1967676683A5047159128 @default.
• W1967676683 hasAuthorship W1967676683A5047229428 @default.
• W1967676683 hasAuthorship W1967676683A5054949108 @default.
• W1967676683 hasAuthorship W1967676683A5057773812 @default.
• W1967676683 hasAuthorship W1967676683A5058150471 @default.
• W1967676683 hasAuthorship W1967676683A5060445702 @default.

• next