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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967684716> ?p ?o ?g. }

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• W1967684716 abstract "Although transmission of human immunodeficiency virus type 1 (HIV-1) from mother to infant has been well documented during pregnancy and delivery, little is known about the possible transmission of HIV-1 during the postnatal period.We conducted a prospective cohort study in Kigali, Rwanda, of 212 mother-infant pairs who were seronegative for HIV-1 at delivery. All the infants were breast-fed. The subjects were followed at three-month intervals, with Western blot assays for antibodies to HIV-1 and testing of mononuclear cells by a double polymerase chain reaction (PCR) using three sets of primers. To evaluate potential risk factors, each mother who seroconverted was matched with three seronegative control women.After a mean follow-up of 16.6 months, 16 of the 212 mothers became seropositive for HIV-1. Of their 16 infants, 9 became seropositive. One infant was excluded from the analysis because of a positive test by PCR on the blood sample obtained at birth. Postnatal seroconversion to HIV-1 occurred in four of the five infants born to the mothers who seroconverted during the first 3 months post partum, and in four infants of the 10 mothers who seroconverted between month 4 and month 21. In all cases, the infant seroconverted during the same three-month period as the mother. The main risk factor for maternal seroconversion was being single.HIV-1 infection can be transmitted from mothers to infants during the postnatal period. Colostrum and breast milk may be efficient routes for the transmission of HIV-1 from recently infected mothers to their infants." @default.
• W1967684716 created "2016-06-24" @default.
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• W1967684716 date "1991-08-29" @default.
• W1967684716 modified "2023-10-17" @default.
• W1967684716 title "Postnatal Transmission of Human Immunodeficiency Virus Type 1 from Mother to Infant" @default.
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• W1967684716 doi "https://doi.org/10.1056/nejm199108293250901" @default.
• W1967684716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1812850" @default.
• W1967684716 hasPublicationYear "1991" @default.
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