Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967692138> ?p ?o ?g. }
- W1967692138 endingPage "605" @default.
- W1967692138 startingPage "596" @default.
- W1967692138 abstract "Peroxisome proliferator-activated receptor-γ (PPARγ) is a nuclear receptor with transcriptional activity controlling multiple physical and pathological processes. Recently, PPARγ has been implicated in the pathogenesis of liver fibrosis. Its depleted expression has strong associations with the activation and transdifferentiation of hepatic stellate cells, the central event in liver fibrogenesis. Studies over the past decade demonstrate that PPARγ cross-regulates a number of signaling pathways mediated by growth factors and adipokines, and cellular events including apoptosis and senescence. These signaling and cellular events and their molecular interactions with PPARγ system are profoundly involved in liver fibrogenesis. We critically summarize these mechanistic insights into the PPARγ regulation in liver fibrogenesis based on the updated findings in this area. We conclude with a discussion of the impacts of these discoveries on the interpretation of liver fibrogenesis and their potential therapeutic implications. PPARγ activation could be a promising strategy for antifibrotic therapy." @default.
- W1967692138 created "2016-06-24" @default.
- W1967692138 creator A5045336307 @default.
- W1967692138 creator A5052274720 @default.
- W1967692138 creator A5074514967 @default.
- W1967692138 date "2012-03-01" @default.
- W1967692138 modified "2023-09-26" @default.
- W1967692138 title "Peroxisome proliferator-activated receptor-γ cross-regulation of signaling events implicated in liver fibrogenesis" @default.
- W1967692138 cites W1522985778 @default.
- W1967692138 cites W1553157598 @default.
- W1967692138 cites W1589324397 @default.
- W1967692138 cites W1589804686 @default.
- W1967692138 cites W1639924204 @default.
- W1967692138 cites W169476524 @default.
- W1967692138 cites W1964082391 @default.
- W1967692138 cites W1966064283 @default.
- W1967692138 cites W1966120797 @default.
- W1967692138 cites W1966975625 @default.
- W1967692138 cites W1967083598 @default.
- W1967692138 cites W1968375269 @default.
- W1967692138 cites W1970779494 @default.
- W1967692138 cites W1970924670 @default.
- W1967692138 cites W1971411560 @default.
- W1967692138 cites W1972167901 @default.
- W1967692138 cites W1972530906 @default.
- W1967692138 cites W1975396342 @default.
- W1967692138 cites W1975843538 @default.
- W1967692138 cites W1976599453 @default.
- W1967692138 cites W1976825452 @default.
- W1967692138 cites W1978514461 @default.
- W1967692138 cites W1978701318 @default.
- W1967692138 cites W1978898098 @default.
- W1967692138 cites W1980464176 @default.
- W1967692138 cites W1980792888 @default.
- W1967692138 cites W1981072482 @default.
- W1967692138 cites W1985627033 @default.
- W1967692138 cites W1987052942 @default.
- W1967692138 cites W1987291131 @default.
- W1967692138 cites W1987396009 @default.
- W1967692138 cites W1988345602 @default.
- W1967692138 cites W1989875240 @default.
- W1967692138 cites W1990034749 @default.
- W1967692138 cites W1990047596 @default.
- W1967692138 cites W1990362001 @default.
- W1967692138 cites W1996569902 @default.
- W1967692138 cites W2000002411 @default.
- W1967692138 cites W2001238651 @default.
- W1967692138 cites W2002415424 @default.
- W1967692138 cites W2002999999 @default.
- W1967692138 cites W2004267786 @default.
- W1967692138 cites W2004273407 @default.
- W1967692138 cites W2004981017 @default.
- W1967692138 cites W2006574739 @default.
- W1967692138 cites W2007955597 @default.
- W1967692138 cites W2009995147 @default.
- W1967692138 cites W2010042337 @default.
- W1967692138 cites W2012225322 @default.
- W1967692138 cites W2012378866 @default.
- W1967692138 cites W2014617922 @default.
- W1967692138 cites W2016611373 @default.
- W1967692138 cites W2017961355 @default.
- W1967692138 cites W2020329030 @default.
- W1967692138 cites W2020573317 @default.
- W1967692138 cites W2020766314 @default.
- W1967692138 cites W2023565218 @default.
- W1967692138 cites W2025120851 @default.
- W1967692138 cites W2025657436 @default.
- W1967692138 cites W2026178539 @default.
- W1967692138 cites W2028545958 @default.
- W1967692138 cites W2030841602 @default.
- W1967692138 cites W2036411709 @default.
- W1967692138 cites W2037733084 @default.
- W1967692138 cites W2038203832 @default.
- W1967692138 cites W2042605274 @default.
- W1967692138 cites W2042663683 @default.
- W1967692138 cites W2043577247 @default.
- W1967692138 cites W2043673064 @default.
- W1967692138 cites W2045855629 @default.
- W1967692138 cites W2047988288 @default.
- W1967692138 cites W2049330787 @default.
- W1967692138 cites W2050096162 @default.
- W1967692138 cites W2050360984 @default.
- W1967692138 cites W2051329702 @default.
- W1967692138 cites W2051923547 @default.
- W1967692138 cites W2055137884 @default.
- W1967692138 cites W2055421563 @default.
- W1967692138 cites W2055628636 @default.
- W1967692138 cites W2055635848 @default.
- W1967692138 cites W2057095258 @default.
- W1967692138 cites W2057265759 @default.
- W1967692138 cites W2057765165 @default.
- W1967692138 cites W2060064616 @default.
- W1967692138 cites W2064227724 @default.
- W1967692138 cites W2064757898 @default.
- W1967692138 cites W2066673068 @default.
- W1967692138 cites W2066699861 @default.
- W1967692138 cites W2066768427 @default.
- W1967692138 cites W2070393128 @default.