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- W1967695355 abstract "RK-1409B, a new inhibitor of protein kinase C, was isolated from the culture broth of Streptomyces platensis subsp. malvinus RK-1409. The structure was elucidated on the basis of spectroscopic analyses. RK-1409B inhibited protein kinase C in vitro and the morphological change of a human chronic leukemia cell line, K-562, induced by phorbol 12,13-dibutyrate with IC50 value of 0.4 microM." @default.
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- W1967695355 date "1992-01-01" @default.
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- W1967695355 title "A new inhibitor of protein kinase C, RK-1409B (4'-demethylamino-4'-hydroxy-3'-epistaurosporine)." @default.
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- W1967695355 doi "https://doi.org/10.7164/antibiotics.45.1428" @default.
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