FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967695483> ?p ?o ?g. }

• W1967695483 endingPage "8998" @default.
• W1967695483 startingPage "8988" @default.
• W1967695483 abstract "Protein motifs represent highly conserved regions within protein families and are generally accepted to describe critical regions required for protein stability and/or function. In this comprehensive analysis, we present a robust, unique approach to identify and compare corresponding mesophilic and thermophilic sequence motifs between all orthologous proteins within 44 microbial genomes. Motif similarity is determined through global sequence alignment of mesophilic and thermophilic motif pairs, which are identified by a greedy algorithm. Our results reveal only modest correlation between motif and overall sequence similarity, highlighting the rationale of motif-based approaches in comprehensive multigenome comparisons. Conserved mutations reflect previously suggested physiochemical principles for conferring thermostability. Additionally, comparisons between corresponding mesophilic and thermophilic motif pairs provide key biochemical insights related to thermostability and can be used to test the evolutionary robustness of individual structural comparisons. We demonstrate the ability of our unique approach to provide key insights in two examples: the TATA-box binding protein and glutamate dehydrogenase families. In the latter example, conserved mutations hint at novel origins leading to structural stability differences within the hexamer structures. Additionally, we present amino acid composition data and average protein length comparisons for all 44 microbial genomes." @default.
• W1967695483 created "2016-06-24" @default.
• W1967695483 creator A5041771738 @default.
• W1967695483 creator A5054458396 @default.
• W1967695483 creator A5077667471 @default.
• W1967695483 creator A5087147388 @default.
• W1967695483 date "2003-07-09" @default.
• W1967695483 modified "2023-10-10" @default.
• W1967695483 title "Using Motif-Based Methods in Multiple Genome Analyses: A Case Study Comparing Orthologous Mesophilic and Thermophilic Proteins†" @default.
• W1967695483 cites W1563999781 @default.
• W1967695483 cites W1655181852 @default.
• W1967695483 cites W1971827772 @default.
• W1967695483 cites W2008672089 @default.
• W1967695483 cites W2009434581 @default.
• W1967695483 cites W2016301662 @default.
• W1967695483 cites W2029316600 @default.
• W1967695483 cites W2035546546 @default.
• W1967695483 cites W2036866029 @default.
• W1967695483 cites W2090778342 @default.
• W1967695483 cites W2092236410 @default.
• W1967695483 cites W2092485312 @default.
• W1967695483 cites W2096962761 @default.
• W1967695483 cites W2097455735 @default.
• W1967695483 cites W2101135427 @default.
• W1967695483 cites W2102122585 @default.
• W1967695483 cites W2133790733 @default.
• W1967695483 cites W2140833414 @default.
• W1967695483 cites W2142843496 @default.
• W1967695483 cites W2158476854 @default.
• W1967695483 cites W2158543301 @default.
• W1967695483 cites W2169929748 @default.
• W1967695483 cites W4248350517 @default.
• W1967695483 cites W4256308970 @default.
• W1967695483 doi "https://doi.org/10.1021/bi027435e" @default.
• W1967695483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12885231" @default.
• W1967695483 hasPublicationYear "2003" @default.
• W1967695483 type Work @default.
• W1967695483 sameAs 1967695483 @default.
• W1967695483 citedByCount "22" @default.
• W1967695483 countsByYear W19676954832012 @default.
• W1967695483 countsByYear W19676954832013 @default.
• W1967695483 countsByYear W19676954832017 @default.
• W1967695483 countsByYear W19676954832023 @default.
• W1967695483 crossrefType "journal-article" @default.
• W1967695483 hasAuthorship W1967695483A5041771738 @default.
• W1967695483 hasAuthorship W1967695483A5054458396 @default.
• W1967695483 hasAuthorship W1967695483A5077667471 @default.
• W1967695483 hasAuthorship W1967695483A5087147388 @default.
• W1967695483 hasConcept C10010492 @default.
• W1967695483 hasConcept C104317684 @default.
• W1967695483 hasConcept C132677234 @default.
• W1967695483 hasConcept C141231307 @default.
• W1967695483 hasConcept C167625842 @default.
• W1967695483 hasConcept C181199279 @default.
• W1967695483 hasConcept C189754071 @default.
• W1967695483 hasConcept C24432333 @default.
• W1967695483 hasConcept C2776027139 @default.
• W1967695483 hasConcept C2781216036 @default.
• W1967695483 hasConcept C27911776 @default.
• W1967695483 hasConcept C45484198 @default.
• W1967695483 hasConcept C523546767 @default.
• W1967695483 hasConcept C54355233 @default.
• W1967695483 hasConcept C55493867 @default.
• W1967695483 hasConcept C70721500 @default.
• W1967695483 hasConcept C86803240 @default.
• W1967695483 hasConcept C88031987 @default.
• W1967695483 hasConceptScore W1967695483C10010492 @default.
• W1967695483 hasConceptScore W1967695483C104317684 @default.
• W1967695483 hasConceptScore W1967695483C132677234 @default.
• W1967695483 hasConceptScore W1967695483C141231307 @default.
• W1967695483 hasConceptScore W1967695483C167625842 @default.
• W1967695483 hasConceptScore W1967695483C181199279 @default.
• W1967695483 hasConceptScore W1967695483C189754071 @default.
• W1967695483 hasConceptScore W1967695483C24432333 @default.
• W1967695483 hasConceptScore W1967695483C2776027139 @default.
• W1967695483 hasConceptScore W1967695483C2781216036 @default.
• W1967695483 hasConceptScore W1967695483C27911776 @default.
• W1967695483 hasConceptScore W1967695483C45484198 @default.
• W1967695483 hasConceptScore W1967695483C523546767 @default.
• W1967695483 hasConceptScore W1967695483C54355233 @default.
• W1967695483 hasConceptScore W1967695483C55493867 @default.
• W1967695483 hasConceptScore W1967695483C70721500 @default.
• W1967695483 hasConceptScore W1967695483C86803240 @default.
• W1967695483 hasConceptScore W1967695483C88031987 @default.
• W1967695483 hasIssue "30" @default.
• W1967695483 hasLocation W19676954831 @default.
• W1967695483 hasLocation W19676954832 @default.
• W1967695483 hasOpenAccess W1967695483 @default.
• W1967695483 hasPrimaryLocation W19676954831 @default.
• W1967695483 hasRelatedWork W2061042699 @default.
• W1967695483 hasRelatedWork W2087687984 @default.
• W1967695483 hasRelatedWork W2185276424 @default.
• W1967695483 hasRelatedWork W2208708370 @default.
• W1967695483 hasRelatedWork W2315686924 @default.
• W1967695483 hasRelatedWork W2804480386 @default.
• W1967695483 hasRelatedWork W3021425989 @default.
• W1967695483 hasRelatedWork W3186624150 @default.
• W1967695483 hasRelatedWork W4315621825 @default.

• next