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- W1967701574 abstract "Cellular homeostasis is linked tightly to mitochondrial functions. Some damage to mitochondrial proteins and nucleic acids can lead to the depolarization of the inner mitochondrial membrane, thereby sensitizing impaired mitochondria for selective elimination by autophagy. Mitochondrial dysfunction is one of the key aspects of the pathobiology of neurodegenerative disease. Parkin, an E3 ligase located in the cytosol and originally discovered as mutated in monogenic forms of Parkinson's disease (PD), was found recently to translocate specifically to uncoupled mitochondria and to induce their autophagy." @default.
- W1967701574 created "2016-06-24" @default.
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- W1967701574 date "2010-02-25" @default.
- W1967701574 modified "2023-09-26" @default.
- W1967701574 title "Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network" @default.
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- W1967701574 doi "https://doi.org/10.1016/j.febslet.2010.02.060" @default.
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