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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967713105> ?p ?o ?g. }

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• W1967713105 abstract "The synthesis and structure-activity relationship study of a series of 1-indol-1-yl-3-phenoxypropan-2-one inhibitors of cytosolic phospholipase A(2)alpha (cPLA(2)alpha) are described. The compounds were evaluated in a vesicle assay with isolated cPLA(2)alpha and in cellular assays with intact human platelets. Systematic variation led to 3-methylhydrogen 1-[3-(4-decyloxyphenoxy)-2-oxopropyl]indole-3,5-dicarboxylate (57), which revealed the highest activity against the isolated enzyme. With an IC(50) value of 4.3 nM in this assay, it is one of the most potent in vitro cPLA(2)alpha inhibitors known today." @default.
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• W1967713105 date "2006-03-28" @default.
• W1967713105 modified "2023-09-29" @default.
• W1967713105 title "Design and Synthesis of 1-Indol-1-yl-propan-2-ones as Inhibitors of Human Cytosolic Phospholipase A₂α" @default.
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• W1967713105 doi "https://doi.org/10.1021/jm051243a" @default.
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