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• W1967722810 startingPage "60" @default.
• W1967722810 abstract "The Fischer 344 (F344) and Lewis (LEW) rat strains are genetically divergent populations that are used to study the effects of and responses to drugs of abuse. In this context, LEW rats display faster acquisition of drug self-administration than F344 rats. Interestingly, these strains have also been reported to differ in their somatic responses to morphine withdrawal. To address possible strain differences in the affective response to withdrawal, the present study assessed the ability of naloxone-precipitated withdrawal from morphine to induce conditioned taste aversions in male F344 and LEW rats. Specifically, subjects from each of these strains were given chronic morphine to induce dependence and then given access to a novel saccharin solution followed by naloxone. These pairings were given every fourth day for a total of two conditioning trials after which subjects were given access to saccharin but without naloxone administration to assess extinction of the naloxone-induced aversion. Behavioral assays of withdrawal were also performed after each naloxone administration. Both F344 and LEW subjects acquired aversions to the naloxone-associated taste with no significant differences in the rate of acquisition of the aversions. Differences did appear during extinction with LEW animals extinguishing the taste aversion significantly faster than F344 animals. The data were discussed in terms of the relative strength of the affective responses during withdrawal and the role of such responses to drug use and abuse." @default.
• W1967722810 created "2016-06-24" @default.
• W1967722810 creator A5060070540 @default.
• W1967722810 creator A5065148215 @default.
• W1967722810 date "2009-03-01" @default.
• W1967722810 modified "2023-09-23" @default.
• W1967722810 title "Naloxone-precipitated conditioned taste aversions in morphine-dependent Fischer (F344) and Lewis rat strains" @default.
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• W1967722810 doi "https://doi.org/10.1016/j.pbb.2008.10.011" @default.
• W1967722810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19000706" @default.
• W1967722810 hasPublicationYear "2009" @default.
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