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• W1967722934 abstract "Two new spirooxindole alkaloids spindomycins A ( 1 ) and B ( 2 ) were isolated from rhizosphere strain Streptomyces sp . xzqh-9. Their structures were elucidated by comprehensive spectroscopic analyses of NMR and MS data. The absolute configurations of 1 and 2 were determined by experimental and theoretical calculation of electronic circular dichroism (ECD). Antitumor, lactate dehydrogenase, and tyrosine kinase inhibitory activities of two compounds were evaluated, while only spindomycin B ( 2 ) exhibited weak inhibitory activity against tyrosine kinase Bcr-Abl. Two new spirooxindole alkaloids spindomycins A ( 1 ) and B ( 2 ) were isolated from rhizosphere strain Streptomyces sp . xzqh-9. Their structures were elucidated by comprehensive spectroscopic analyses of NMR and MS data. The absolute configurations of 1 and 2 were determined by experimental and theoretical calculation of electronic circular dichroism (ECD). Antitumor, lactate dehydrogenase, and tyrosine kinase inhibitory activities of two compounds were evaluated, while only spindomycin B ( 2 ) exhibited weak inhibitory activity against tyrosine kinase Bcr-Abl." @default.
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• W1967722934 date "2014-11-01" @default.
• W1967722934 modified "2023-10-15" @default.
• W1967722934 title "Two new spirooxindole alkaloids from rhizosphere strain Streptomyces sp. xzqh-9" @default.
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• W1967722934 doi "https://doi.org/10.1016/j.bmcl.2014.09.026" @default.
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