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- W1967728488 endingPage "73" @default.
- W1967728488 startingPage "62" @default.
- W1967728488 abstract "The serine–threonine phosphatase calcineurin is activated in cardiac myocytes in the diseased heart and induces pathological hypertrophy. Calcineurin activity is mainly triggered by calcium/calmodulin binding but also through calpain mediated cleavage. How controlled calcineurin activation is possible in cardiac myocytes, which typically show a 10-fold difference in cytosolic calcium concentration with every heartbeat, has remained enigmatic. It is now emerging that calcineurin activation and signaling occur in subcellular microdomains, in which it is brought together with target proteins and exceedingly high concentrations of calcium in order to induce downstream signaling. We review current evidence of subcellular calcineurin mainly at the sarcolemma and the nucleus, but also in association with the sarcoplasmic reticulum and mitochondria. We also suggest that knowledge about subcellular signaling could help to develop inhibitors of calcineurin in specific microdomains to avoid side-effects that may arise from complete calcineurin inhibition." @default.
- W1967728488 created "2016-06-24" @default.
- W1967728488 creator A5029453843 @default.
- W1967728488 creator A5038620753 @default.
- W1967728488 date "2012-01-01" @default.
- W1967728488 modified "2023-10-17" @default.
- W1967728488 title "Cardiomyocyte calcineurin signaling in subcellular domains: From the sarcolemma to the nucleus and beyond" @default.
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