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- W1967738808 abstract "Proteoglycans, extracellular matrix components, exert several activities on bone cells and seem crucial for maintaining an appropriate number of osteoblasts and osteoclasts. The overall data strengthen a pro-bone resorptive role for proteoglycans, through the control of osteoprotegerin availability and of receptor activator of NF-κB ligand bioactivity. In parallel, proteoglycans participate in the control of tumor development at different levels, including bone tumor development and bone metastases dissemination. This dual role makes them good candidates as regulatory molecules in the vicious cycle between tumor proliferation and bone resorption observed during tumor development in bone site. Knowledge of the biological roles of these molecules in cancer biology, tumor angiogenesis and metastasis has promoted the development of drugs targeting them." @default.
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- W1967738808 date "2010-07-01" @default.
- W1967738808 modified "2023-09-30" @default.
- W1967738808 title "Proteoglycans on bone tumor development" @default.
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- W1967738808 doi "https://doi.org/10.1016/j.drudis.2010.05.009" @default.
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