Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967753990> ?p ?o ?g. }
- W1967753990 endingPage "33347" @default.
- W1967753990 startingPage "33338" @default.
- W1967753990 abstract "Porphyromonas gingivalis, a pathogen that causes inflammation in human periodontal tissue, killed silkworm (Bombyx mori, Lepidoptera) larvae when injected into the blood (hemolymph). Silkworm lethality was not rescued by antibiotic treatment, and heat-killed bacteria were also lethal. Heat-killed bacteria of mutant P. gingivalis strains lacking virulence factors also killed silkworms. Silkworms died after injection of peptidoglycans purified from P. gingivalis (pPG), and pPG toxicity was blocked by treatment with mutanolysin, a peptidoglycan-degrading enzyme. pPG induced silkworm hemolymph melanization at the same dose as that required to kill the animal. pPG injection increased caspase activity in silkworm tissues. pPG-induced silkworm death was delayed by injecting melanization-inhibiting reagents (a serine protease inhibitor and 1-phenyl-2-thiourea), antioxidants (N-acetyl-l-cysteine, glutathione, and catalase), and a caspase inhibitor (Ac-DEVD-CHO). Thus, pPG induces excessive activation of the innate immune response, which leads to the generation of reactive oxygen species and apoptotic cell death in the host tissue." @default.
- W1967753990 created "2016-06-24" @default.
- W1967753990 creator A5003851517 @default.
- W1967753990 creator A5021606637 @default.
- W1967753990 creator A5061673601 @default.
- W1967753990 creator A5067467084 @default.
- W1967753990 creator A5076302608 @default.
- W1967753990 creator A5082378325 @default.
- W1967753990 creator A5088413991 @default.
- W1967753990 date "2010-10-01" @default.
- W1967753990 modified "2023-10-16" @default.
- W1967753990 title "Porphyromonas gingivalis Peptidoglycans Induce Excessive Activation of the Innate Immune System in Silkworm Larvae*" @default.
- W1967753990 cites W1550231363 @default.
- W1967753990 cites W184894184 @default.
- W1967753990 cites W1963651926 @default.
- W1967753990 cites W1969571975 @default.
- W1967753990 cites W1970259317 @default.
- W1967753990 cites W1974670485 @default.
- W1967753990 cites W1978014890 @default.
- W1967753990 cites W1980104121 @default.
- W1967753990 cites W1982264720 @default.
- W1967753990 cites W1990099384 @default.
- W1967753990 cites W1994391912 @default.
- W1967753990 cites W1999771775 @default.
- W1967753990 cites W2002835408 @default.
- W1967753990 cites W2005166322 @default.
- W1967753990 cites W2017482741 @default.
- W1967753990 cites W2018658170 @default.
- W1967753990 cites W2020104033 @default.
- W1967753990 cites W2021331037 @default.
- W1967753990 cites W2022205990 @default.
- W1967753990 cites W2022212425 @default.
- W1967753990 cites W2023683814 @default.
- W1967753990 cites W2042824737 @default.
- W1967753990 cites W2044105466 @default.
- W1967753990 cites W2048644187 @default.
- W1967753990 cites W2053344942 @default.
- W1967753990 cites W2053995411 @default.
- W1967753990 cites W2056077453 @default.
- W1967753990 cites W2057809738 @default.
- W1967753990 cites W2064647551 @default.
- W1967753990 cites W2067459912 @default.
- W1967753990 cites W2074811101 @default.
- W1967753990 cites W2079639127 @default.
- W1967753990 cites W2093201675 @default.
- W1967753990 cites W2101830724 @default.
- W1967753990 cites W2124154779 @default.
- W1967753990 cites W2127152427 @default.
- W1967753990 cites W2132396239 @default.
- W1967753990 cites W2144420494 @default.
- W1967753990 cites W2151272921 @default.
- W1967753990 cites W2152457344 @default.
- W1967753990 cites W2153643161 @default.
- W1967753990 cites W2153920932 @default.
- W1967753990 cites W2157379357 @default.
- W1967753990 cites W2159052720 @default.
- W1967753990 cites W2159728493 @default.
- W1967753990 cites W2166313509 @default.
- W1967753990 doi "https://doi.org/10.1074/jbc.m110.112987" @default.
- W1967753990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2963355" @default.
- W1967753990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20702417" @default.
- W1967753990 hasPublicationYear "2010" @default.
- W1967753990 type Work @default.
- W1967753990 sameAs 1967753990 @default.
- W1967753990 citedByCount "50" @default.
- W1967753990 countsByYear W19677539902012 @default.
- W1967753990 countsByYear W19677539902013 @default.
- W1967753990 countsByYear W19677539902014 @default.
- W1967753990 countsByYear W19677539902015 @default.
- W1967753990 countsByYear W19677539902017 @default.
- W1967753990 countsByYear W19677539902018 @default.
- W1967753990 countsByYear W19677539902019 @default.
- W1967753990 countsByYear W19677539902020 @default.
- W1967753990 countsByYear W19677539902021 @default.
- W1967753990 countsByYear W19677539902022 @default.
- W1967753990 countsByYear W19677539902023 @default.
- W1967753990 crossrefType "journal-article" @default.
- W1967753990 hasAuthorship W1967753990A5003851517 @default.
- W1967753990 hasAuthorship W1967753990A5021606637 @default.
- W1967753990 hasAuthorship W1967753990A5061673601 @default.
- W1967753990 hasAuthorship W1967753990A5067467084 @default.
- W1967753990 hasAuthorship W1967753990A5076302608 @default.
- W1967753990 hasAuthorship W1967753990A5082378325 @default.
- W1967753990 hasAuthorship W1967753990A5088413991 @default.
- W1967753990 hasBestOaLocation W19677539901 @default.
- W1967753990 hasConcept C100068826 @default.
- W1967753990 hasConcept C104317684 @default.
- W1967753990 hasConcept C136449434 @default.
- W1967753990 hasConcept C181199279 @default.
- W1967753990 hasConcept C182220744 @default.
- W1967753990 hasConcept C203014093 @default.
- W1967753990 hasConcept C205260736 @default.
- W1967753990 hasConcept C2778487026 @default.
- W1967753990 hasConcept C2780183776 @default.
- W1967753990 hasConcept C523546767 @default.
- W1967753990 hasConcept C54355233 @default.
- W1967753990 hasConcept C55493867 @default.
- W1967753990 hasConcept C86803240 @default.