Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967777775> ?p ?o ?g. }
- W1967777775 endingPage "403" @default.
- W1967777775 startingPage "391" @default.
- W1967777775 abstract "Higher order chromatin organization in concert with epigenetic regulation is a key process that determines gene expression at the global level. The organization of dynamic chromatin domains and their associated protein factors is intertwined with nuclear function to create higher levels of functional zones within the cell nucleus. As a step towards elucidating the organization and dynamics of these functional zones, we have investigated the spatial proximities among a constellation of functionally related sites that are found within euchromatic regions of the cell nucleus including: HP1gamma, nascent transcript sites (TS), active DNA replicating sites in early S-phase (PCNA) and RNA polymerase II sites. We report close associations among these different sites with proximity values specific for each combination. Analysis of matrin 3 and SAF-A sites demonstrates that these nuclear matrix proteins are highly proximal with the functionally related sites as well as to each other and display closely aligned and overlapping regions following application of the minimal spanning tree (MST) algorithm to visualize higher order network-like patterns. Our findings suggest that multiple factors within the nuclear microenvironment collectively form higher order combinatorial arrays of function. We propose a model for the organization of these functional neighborhoods which takes into account the proximity values of the individual sites and their spatial organization within the nuclear architecture." @default.
- W1967777775 created "2016-06-24" @default.
- W1967777775 creator A5006945148 @default.
- W1967777775 creator A5011131850 @default.
- W1967777775 creator A5037011704 @default.
- W1967777775 creator A5042070897 @default.
- W1967777775 creator A5046129333 @default.
- W1967777775 creator A5054642319 @default.
- W1967777775 creator A5071750598 @default.
- W1967777775 date "2008-07-10" @default.
- W1967777775 modified "2023-10-16" @default.
- W1967777775 title "Identifying functional neighborhoods within the cell nucleus: Proximity analysis of early S-phase replicating chromatin domains to sites of transcription, RNA polymerase II, HP1γ, matrin 3 and SAF-A" @default.
- W1967777775 cites W1480912438 @default.
- W1967777775 cites W1483692899 @default.
- W1967777775 cites W1504251053 @default.
- W1967777775 cites W1529048149 @default.
- W1967777775 cites W1543627230 @default.
- W1967777775 cites W1544820414 @default.
- W1967777775 cites W1780177435 @default.
- W1967777775 cites W1919219661 @default.
- W1967777775 cites W1919634504 @default.
- W1967777775 cites W1963652893 @default.
- W1967777775 cites W1963696308 @default.
- W1967777775 cites W1965629414 @default.
- W1967777775 cites W1968460162 @default.
- W1967777775 cites W1971045116 @default.
- W1967777775 cites W1971883493 @default.
- W1967777775 cites W1974117230 @default.
- W1967777775 cites W1978113466 @default.
- W1967777775 cites W1980538696 @default.
- W1967777775 cites W1982845316 @default.
- W1967777775 cites W1989522197 @default.
- W1967777775 cites W1994943629 @default.
- W1967777775 cites W1998205522 @default.
- W1967777775 cites W1999155341 @default.
- W1967777775 cites W1999929048 @default.
- W1967777775 cites W2002245835 @default.
- W1967777775 cites W2005711334 @default.
- W1967777775 cites W2006048118 @default.
- W1967777775 cites W2006216882 @default.
- W1967777775 cites W2010643258 @default.
- W1967777775 cites W2013906792 @default.
- W1967777775 cites W2021970479 @default.
- W1967777775 cites W2022856115 @default.
- W1967777775 cites W2027249164 @default.
- W1967777775 cites W2028875985 @default.
- W1967777775 cites W2029229130 @default.
- W1967777775 cites W2030714561 @default.
- W1967777775 cites W2030897728 @default.
- W1967777775 cites W2031310237 @default.
- W1967777775 cites W2032052884 @default.
- W1967777775 cites W2034023141 @default.
- W1967777775 cites W2035940687 @default.
- W1967777775 cites W2036648250 @default.
- W1967777775 cites W2040285686 @default.
- W1967777775 cites W2041676007 @default.
- W1967777775 cites W2057777170 @default.
- W1967777775 cites W2064038671 @default.
- W1967777775 cites W2068243457 @default.
- W1967777775 cites W2069590842 @default.
- W1967777775 cites W2076142853 @default.
- W1967777775 cites W2080108863 @default.
- W1967777775 cites W2082627972 @default.
- W1967777775 cites W2083246193 @default.
- W1967777775 cites W2085351745 @default.
- W1967777775 cites W2086145907 @default.
- W1967777775 cites W2087344047 @default.
- W1967777775 cites W2087687809 @default.
- W1967777775 cites W2098549100 @default.
- W1967777775 cites W2108027073 @default.
- W1967777775 cites W2111100235 @default.
- W1967777775 cites W2116989970 @default.
- W1967777775 cites W2123952527 @default.
- W1967777775 cites W2124733101 @default.
- W1967777775 cites W2127252972 @default.
- W1967777775 cites W2129842408 @default.
- W1967777775 cites W2132104511 @default.
- W1967777775 cites W2133112723 @default.
- W1967777775 cites W2135002148 @default.
- W1967777775 cites W2137196963 @default.
- W1967777775 cites W2140789268 @default.
- W1967777775 cites W2146404878 @default.
- W1967777775 cites W2152261934 @default.
- W1967777775 cites W2153016401 @default.
- W1967777775 cites W2155512899 @default.
- W1967777775 cites W2155941870 @default.
- W1967777775 cites W2159342107 @default.
- W1967777775 cites W2162261678 @default.
- W1967777775 cites W2162316859 @default.
- W1967777775 cites W2162692975 @default.
- W1967777775 cites W2170517581 @default.
- W1967777775 cites W2171055843 @default.
- W1967777775 cites W2188480055 @default.
- W1967777775 cites W2299200084 @default.
- W1967777775 cites W2328155295 @default.
- W1967777775 cites W2911302472 @default.
- W1967777775 cites W4238527967 @default.
- W1967777775 doi "https://doi.org/10.1002/jcb.21834" @default.