FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967810537> ?p ?o ?g. }

• W1967810537 endingPage "274" @default.
• W1967810537 startingPage "268" @default.
• W1967810537 abstract "The effect of maprotiline on cytosolic free Ca2+ concentrations ([Ca2+]i) and cell viability was explored in human osteosarcoma cells (MG63), using the fluorescent dyes fura-2 and WST-1, respectively. Maprotiline at concentrations of ≥20 µM increased [Ca2+]i in a concentration-dependent manner. The Ca2+ signal was reduced partly by removing extracellular Ca2+. The maprotiline-induced Ca2+ influx was sensitive to inhibition by aristolochic acid (a phospholipase A2 inhibitor). In Ca2+-free medium, after treatment with 1 µM thapsigargin (an endoplasmic reticulum Ca2+ pump inhibitor), 200 µM maprotiline failed to induce a [Ca2+]i rise. At concentrations of 50–100 µM maprotiline killed cells in a concentration-dependent manner. The cytotoxic effect of 60 µM maprotiline was slightly enhanced by prechelating cytosolic Ca2+ with 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA). Propidium iodide staining data suggested that maprotiline induced apoptosis between concentrations of 60–70 µM, which was enhanced by BAPTA. Collectively, in MG63 cells, maprotiline induced [Ca2+]i rises by causing Ca2+ release from the endoplasmic reticulum and Ca2+ influx from phospholipase A2-regulated Ca2+ channels. Furthermore, maprotiline caused apoptosis that was regulated by Ca2+. Drug Dev Res 71: 268–274, 2010. © 2010 Wiley-Liss, Inc." @default.
• W1967810537 created "2016-06-24" @default.
• W1967810537 creator A5021798410 @default.
• W1967810537 creator A5027423438 @default.
• W1967810537 creator A5029723976 @default.
• W1967810537 creator A5042693993 @default.
• W1967810537 creator A5051181586 @default.
• W1967810537 creator A5054056894 @default.
• W1967810537 creator A5063217295 @default.
• W1967810537 creator A5065294447 @default.
• W1967810537 creator A5073200348 @default.
• W1967810537 creator A5076143620 @default.
• W1967810537 creator A5089722538 @default.
• W1967810537 date "2010-05-21" @default.
• W1967810537 modified "2023-10-16" @default.
• W1967810537 title "Maprotiline-induced Ca2+ fluxes and apoptosis in human osteosarcoma cells" @default.
• W1967810537 cites W1863626133 @default.
• W1967810537 cites W1964372552 @default.
• W1967810537 cites W1982669604 @default.
• W1967810537 cites W1986556598 @default.
• W1967810537 cites W1988418770 @default.
• W1967810537 cites W1996128327 @default.
• W1967810537 cites W1997332730 @default.
• W1967810537 cites W2001534460 @default.
• W1967810537 cites W2007219916 @default.
• W1967810537 cites W2012449496 @default.
• W1967810537 cites W2012981304 @default.
• W1967810537 cites W2016148363 @default.
• W1967810537 cites W2017459465 @default.
• W1967810537 cites W2019083595 @default.
• W1967810537 cites W2020675288 @default.
• W1967810537 cites W2022682609 @default.
• W1967810537 cites W2025049315 @default.
• W1967810537 cites W2039600625 @default.
• W1967810537 cites W2058449890 @default.
• W1967810537 cites W2062676490 @default.
• W1967810537 cites W2063535351 @default.
• W1967810537 cites W2072442505 @default.
• W1967810537 cites W2080091995 @default.
• W1967810537 cites W2080669304 @default.
• W1967810537 cites W2086898247 @default.
• W1967810537 cites W2089931823 @default.
• W1967810537 cites W2091474460 @default.
• W1967810537 cites W2101300328 @default.
• W1967810537 cites W2101397295 @default.
• W1967810537 cites W2114164865 @default.
• W1967810537 cites W2125226494 @default.
• W1967810537 cites W2141260882 @default.
• W1967810537 cites W2144530288 @default.
• W1967810537 cites W2145029393 @default.
• W1967810537 cites W2158114348 @default.
• W1967810537 cites W2160873790 @default.
• W1967810537 cites W77021389 @default.
• W1967810537 doi "https://doi.org/10.1002/ddr.20371" @default.
• W1967810537 hasPublicationYear "2010" @default.
• W1967810537 type Work @default.
• W1967810537 sameAs 1967810537 @default.
• W1967810537 citedByCount "4" @default.
• W1967810537 countsByYear W19678105372014 @default.
• W1967810537 countsByYear W19678105372022 @default.
• W1967810537 crossrefType "journal-article" @default.
• W1967810537 hasAuthorship W1967810537A5021798410 @default.
• W1967810537 hasAuthorship W1967810537A5027423438 @default.
• W1967810537 hasAuthorship W1967810537A5029723976 @default.
• W1967810537 hasAuthorship W1967810537A5042693993 @default.
• W1967810537 hasAuthorship W1967810537A5051181586 @default.
• W1967810537 hasAuthorship W1967810537A5054056894 @default.
• W1967810537 hasAuthorship W1967810537A5063217295 @default.
• W1967810537 hasAuthorship W1967810537A5065294447 @default.
• W1967810537 hasAuthorship W1967810537A5073200348 @default.
• W1967810537 hasAuthorship W1967810537A5076143620 @default.
• W1967810537 hasAuthorship W1967810537A5089722538 @default.
• W1967810537 hasConcept C134018914 @default.
• W1967810537 hasConcept C153911025 @default.
• W1967810537 hasConcept C158617107 @default.
• W1967810537 hasConcept C181199279 @default.
• W1967810537 hasConcept C185592680 @default.
• W1967810537 hasConcept C190283241 @default.
• W1967810537 hasConcept C2775934118 @default.
• W1967810537 hasConcept C2776551241 @default.
• W1967810537 hasConcept C2777146706 @default.
• W1967810537 hasConcept C2778470358 @default.
• W1967810537 hasConcept C2779177272 @default.
• W1967810537 hasConcept C2780019300 @default.
• W1967810537 hasConcept C2780756443 @default.
• W1967810537 hasConcept C2781161787 @default.
• W1967810537 hasConcept C28406088 @default.
• W1967810537 hasConcept C31573885 @default.
• W1967810537 hasConcept C55493867 @default.
• W1967810537 hasConcept C86803240 @default.
• W1967810537 hasConcept C98274493 @default.
• W1967810537 hasConcept C98539663 @default.
• W1967810537 hasConceptScore W1967810537C134018914 @default.
• W1967810537 hasConceptScore W1967810537C153911025 @default.
• W1967810537 hasConceptScore W1967810537C158617107 @default.
• W1967810537 hasConceptScore W1967810537C181199279 @default.
• W1967810537 hasConceptScore W1967810537C185592680 @default.
• W1967810537 hasConceptScore W1967810537C190283241 @default.

• next