Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967814456> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1967814456 endingPage "229" @default.
- W1967814456 startingPage "222" @default.
- W1967814456 abstract "Objective To explore the potential of chip-based capillary electrophoresis for rapid prenatal diagnosis of genetic diseases, we developed a prenatal diagnosis method for β-thalassemia, one of the most common recessive inherited disorders. Method DNA samples containing known mutations of β-thalassemia were used to optimize multiplex allele-specific PCR and chip-based capillary electrophoresis was used to simultaneously detect Cy3-labeled PCR products and Cy5-labeled ladder. This system was validated by detecting 40 unknown cases, 4 of which were processed further for prenatal diagnosis. Results We analyzed previously genotyped samples and unknown samples by this method and the results were concordant with those from reverse dot blot and direct sequencing. Prenatal diagnosis was carried out successfully and rapidly on 1 µL (1 ng/µL) sample in 4 pregnancy cases carrying potential β-thalassemia risk. Conclusion This chip-based capillary electrophoresis detecting system could be used for prenatal diagnosis of β-thalassemia and will facilitate the rapid and sensitive prenatal diagnosis of genetic disorder. Copyright © 2008 John Wiley & Sons, Ltd." @default.
- W1967814456 created "2016-06-24" @default.
- W1967814456 creator A5000673221 @default.
- W1967814456 creator A5028738803 @default.
- W1967814456 creator A5034294282 @default.
- W1967814456 creator A5058598199 @default.
- W1967814456 creator A5082465261 @default.
- W1967814456 creator A5084873999 @default.
- W1967814456 creator A5088634479 @default.
- W1967814456 date "2008-01-01" @default.
- W1967814456 modified "2023-10-03" @default.
- W1967814456 title "Prenatal diagnosis of β-thalassemia by chip-based capillary electrophoresis" @default.
- W1967814456 cites W1483708301 @default.
- W1967814456 cites W1984662125 @default.
- W1967814456 cites W1990692993 @default.
- W1967814456 cites W2003691989 @default.
- W1967814456 cites W2012061944 @default.
- W1967814456 cites W2060884975 @default.
- W1967814456 cites W2100977485 @default.
- W1967814456 cites W2119648269 @default.
- W1967814456 cites W2125642074 @default.
- W1967814456 cites W2132379253 @default.
- W1967814456 cites W2158335690 @default.
- W1967814456 doi "https://doi.org/10.1002/pd.1932" @default.
- W1967814456 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18264955" @default.
- W1967814456 hasPublicationYear "2008" @default.
- W1967814456 type Work @default.
- W1967814456 sameAs 1967814456 @default.
- W1967814456 citedByCount "7" @default.
- W1967814456 countsByYear W19678144562015 @default.
- W1967814456 countsByYear W19678144562019 @default.
- W1967814456 countsByYear W19678144562023 @default.
- W1967814456 crossrefType "journal-article" @default.
- W1967814456 hasAuthorship W1967814456A5000673221 @default.
- W1967814456 hasAuthorship W1967814456A5028738803 @default.
- W1967814456 hasAuthorship W1967814456A5034294282 @default.
- W1967814456 hasAuthorship W1967814456A5058598199 @default.
- W1967814456 hasAuthorship W1967814456A5082465261 @default.
- W1967814456 hasAuthorship W1967814456A5084873999 @default.
- W1967814456 hasAuthorship W1967814456A5088634479 @default.
- W1967814456 hasConcept C104317684 @default.
- W1967814456 hasConcept C116084860 @default.
- W1967814456 hasConcept C153911025 @default.
- W1967814456 hasConcept C172680121 @default.
- W1967814456 hasConcept C180754005 @default.
- W1967814456 hasConcept C2777799968 @default.
- W1967814456 hasConcept C2777940137 @default.
- W1967814456 hasConcept C2778258057 @default.
- W1967814456 hasConcept C2778908642 @default.
- W1967814456 hasConcept C2779234561 @default.
- W1967814456 hasConcept C2781188995 @default.
- W1967814456 hasConcept C2900643 @default.
- W1967814456 hasConcept C2993153387 @default.
- W1967814456 hasConcept C49105822 @default.
- W1967814456 hasConcept C54355233 @default.
- W1967814456 hasConcept C71924100 @default.
- W1967814456 hasConcept C86803240 @default.
- W1967814456 hasConcept C90583042 @default.
- W1967814456 hasConceptScore W1967814456C104317684 @default.
- W1967814456 hasConceptScore W1967814456C116084860 @default.
- W1967814456 hasConceptScore W1967814456C153911025 @default.
- W1967814456 hasConceptScore W1967814456C172680121 @default.
- W1967814456 hasConceptScore W1967814456C180754005 @default.
- W1967814456 hasConceptScore W1967814456C2777799968 @default.
- W1967814456 hasConceptScore W1967814456C2777940137 @default.
- W1967814456 hasConceptScore W1967814456C2778258057 @default.
- W1967814456 hasConceptScore W1967814456C2778908642 @default.
- W1967814456 hasConceptScore W1967814456C2779234561 @default.
- W1967814456 hasConceptScore W1967814456C2781188995 @default.
- W1967814456 hasConceptScore W1967814456C2900643 @default.
- W1967814456 hasConceptScore W1967814456C2993153387 @default.
- W1967814456 hasConceptScore W1967814456C49105822 @default.
- W1967814456 hasConceptScore W1967814456C54355233 @default.
- W1967814456 hasConceptScore W1967814456C71924100 @default.
- W1967814456 hasConceptScore W1967814456C86803240 @default.
- W1967814456 hasConceptScore W1967814456C90583042 @default.
- W1967814456 hasIssue "3" @default.
- W1967814456 hasLocation W19678144561 @default.
- W1967814456 hasLocation W19678144562 @default.
- W1967814456 hasOpenAccess W1967814456 @default.
- W1967814456 hasPrimaryLocation W19678144561 @default.
- W1967814456 hasRelatedWork W111537124 @default.
- W1967814456 hasRelatedWork W1967814456 @default.
- W1967814456 hasRelatedWork W1987020555 @default.
- W1967814456 hasRelatedWork W2044511734 @default.
- W1967814456 hasRelatedWork W2299294290 @default.
- W1967814456 hasRelatedWork W2365857010 @default.
- W1967814456 hasRelatedWork W2407312881 @default.
- W1967814456 hasRelatedWork W2977421726 @default.
- W1967814456 hasRelatedWork W4246646279 @default.
- W1967814456 hasRelatedWork W52447645 @default.
- W1967814456 hasVolume "28" @default.
- W1967814456 isParatext "false" @default.
- W1967814456 isRetracted "false" @default.
- W1967814456 magId "1967814456" @default.
- W1967814456 workType "article" @default.