FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967816717> ?p ?o ?g. }

• W1967816717 endingPage "470" @default.
• W1967816717 startingPage "465" @default.
• W1967816717 abstract "Cold storage in oxygenated perfluorodecalin (PFD) restores transplant function of ischemically damaged dog pancreata and reduces the impact of cold ischemia on recovery of isolated human islets. Whether PFD storage can improve islet isolation from pancreata exposed to significant warm ischemia (WI) is unclear yet. The present study aimed to clarify this question in adult pigs.After exsanguination, the intestine was removed immediately or left in the cavity for 30 min of WI. Resected pancreata were intraductally flushed with cold University of Wisconsin solution. Subsequently, pancreata were processed immediately by digestion-filtration (group I: 0 min WI, n=6; II: 30 min WI, n=6) or first stored for 3 h in oxygenated PFD (III: 0 min WI+PFD, n=5; IV: 30 min WI+PFD, n=6).Pancreata subjected to 30 min of WI yielded significantly less islets compared with the corresponding non-ischemic organs (I vs. II, P<0.01; III vs. IV, P<0.05). Oxygenation did not ameliorate the loss in islet yield (II vs. IV, NS). Ischemic islets were characterized by depleted ATP stores (388+/-73 (I) vs. 133+/-22 ng/1000 IEQ (II), P<0.01) and diminished insulin response to glucose calculated as stimulation index (SI; 2.47+/-0.36 (I) vs. 0.25+/-0.17 (II), P<0.05). PFD storage of ischemic organs partially restored ATP content (217+/-23 ng/1000 IEQ, II vs. IV, P<0.05) and glucose SI (1.60+/-0.09, II vs. IV, P<0.05) to a significant extent that reached the level of corresponding PFD-stored, non-ischemic pancreata (III vs. IV, NS). Sustained normoglycemia was exclusively observed in diabetic nude mice transplanted with islets isolated from non-ischemic organs. The significantly reduced graft function of ischemic islets (I vs. II, III vs. IV, P<0.001) was not increased by pancreatic oxygenation (II vs. IV, NS).The present study suggests that pancreas short-term storage in oxygenated PFD improves in vitro but not the in vivo function of ischemically damaged pig islets." @default.
• W1967816717 created "2016-06-24" @default.
• W1967816717 creator A5002431454 @default.
• W1967816717 creator A5052117911 @default.
• W1967816717 creator A5062096649 @default.
• W1967816717 creator A5085314317 @default.
• W1967816717 date "2006-09-01" @default.
• W1967816717 modified "2023-10-02" @default.
• W1967816717 title "Pancreas storage in oxygenated perfluorodecalin does not restore post-transplant function of isolated pig islets pre-damaged by warm ischemia" @default.
• W1967816717 cites W1462368826 @default.
• W1967816717 cites W1979126743 @default.
• W1967816717 cites W1982129002 @default.
• W1967816717 cites W1985142650 @default.
• W1967816717 cites W1992623347 @default.
• W1967816717 cites W1995893959 @default.
• W1967816717 cites W2004126648 @default.
• W1967816717 cites W2006309409 @default.
• W1967816717 cites W2007522533 @default.
• W1967816717 cites W2017034615 @default.
• W1967816717 cites W2036204182 @default.
• W1967816717 cites W2053577320 @default.
• W1967816717 cites W2056018177 @default.
• W1967816717 cites W2062576688 @default.
• W1967816717 cites W2062959247 @default.
• W1967816717 cites W2070288789 @default.
• W1967816717 cites W2072347280 @default.
• W1967816717 cites W2080272392 @default.
• W1967816717 cites W2084770187 @default.
• W1967816717 cites W2103110619 @default.
• W1967816717 cites W2123861534 @default.
• W1967816717 cites W2143982556 @default.
• W1967816717 cites W2325100310 @default.
• W1967816717 cites W2328786770 @default.
• W1967816717 cites W2398318908 @default.
• W1967816717 cites W2414512167 @default.
• W1967816717 cites W4212796019 @default.
• W1967816717 doi "https://doi.org/10.1111/j.1399-3089.2006.00340.x" @default.
• W1967816717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16925671" @default.
• W1967816717 hasPublicationYear "2006" @default.
• W1967816717 type Work @default.
• W1967816717 sameAs 1967816717 @default.
• W1967816717 citedByCount "26" @default.
• W1967816717 countsByYear W19678167172012 @default.
• W1967816717 countsByYear W19678167172013 @default.
• W1967816717 countsByYear W19678167172014 @default.
• W1967816717 countsByYear W19678167172016 @default.
• W1967816717 countsByYear W19678167172017 @default.
• W1967816717 countsByYear W19678167172018 @default.
• W1967816717 countsByYear W19678167172020 @default.
• W1967816717 countsByYear W19678167172021 @default.
• W1967816717 countsByYear W19678167172022 @default.
• W1967816717 countsByYear W19678167172023 @default.
• W1967816717 crossrefType "journal-article" @default.
• W1967816717 hasAuthorship W1967816717A5002431454 @default.
• W1967816717 hasAuthorship W1967816717A5052117911 @default.
• W1967816717 hasAuthorship W1967816717A5062096649 @default.
• W1967816717 hasAuthorship W1967816717A5085314317 @default.
• W1967816717 hasConcept C126322002 @default.
• W1967816717 hasConcept C134018914 @default.
• W1967816717 hasConcept C144027150 @default.
• W1967816717 hasConcept C165220095 @default.
• W1967816717 hasConcept C185592680 @default.
• W1967816717 hasConcept C2778764654 @default.
• W1967816717 hasConcept C2781357212 @default.
• W1967816717 hasConcept C2911091166 @default.
• W1967816717 hasConcept C2988529969 @default.
• W1967816717 hasConcept C43617362 @default.
• W1967816717 hasConcept C541997718 @default.
• W1967816717 hasConcept C555293320 @default.
• W1967816717 hasConcept C70289976 @default.
• W1967816717 hasConcept C71924100 @default.
• W1967816717 hasConcept C86803240 @default.
• W1967816717 hasConceptScore W1967816717C126322002 @default.
• W1967816717 hasConceptScore W1967816717C134018914 @default.
• W1967816717 hasConceptScore W1967816717C144027150 @default.
• W1967816717 hasConceptScore W1967816717C165220095 @default.
• W1967816717 hasConceptScore W1967816717C185592680 @default.
• W1967816717 hasConceptScore W1967816717C2778764654 @default.
• W1967816717 hasConceptScore W1967816717C2781357212 @default.
• W1967816717 hasConceptScore W1967816717C2911091166 @default.
• W1967816717 hasConceptScore W1967816717C2988529969 @default.
• W1967816717 hasConceptScore W1967816717C43617362 @default.
• W1967816717 hasConceptScore W1967816717C541997718 @default.
• W1967816717 hasConceptScore W1967816717C555293320 @default.
• W1967816717 hasConceptScore W1967816717C70289976 @default.
• W1967816717 hasConceptScore W1967816717C71924100 @default.
• W1967816717 hasConceptScore W1967816717C86803240 @default.
• W1967816717 hasIssue "5" @default.
• W1967816717 hasLocation W19678167171 @default.
• W1967816717 hasLocation W19678167172 @default.
• W1967816717 hasOpenAccess W1967816717 @default.
• W1967816717 hasPrimaryLocation W19678167171 @default.
• W1967816717 hasRelatedWork W1485239067 @default.
• W1967816717 hasRelatedWork W1982624223 @default.
• W1967816717 hasRelatedWork W2017797235 @default.
• W1967816717 hasRelatedWork W2058657286 @default.
• W1967816717 hasRelatedWork W2060319243 @default.
• W1967816717 hasRelatedWork W2062334532 @default.

• next