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- W1967821841 abstract "SUMMARY The diagnostic pathway of lung cancer is a multidisciplinary process that has rapidly changed in the last few years. Most advances relate to lung adenocarcinoma, which needs to be differentiated from squamous cell carcinoma and other histological subtypes, since most targetable mutations occur in adenocarcinomas. Tumor heterogeneity can influence sampling and diagnosis, particularly relevant when using small biopsies or cytology samples. Re-biopsy at progression should become part of the diagnostic process, since it can alter the clinical management, explain mechanisms of resistance to targeted therapy and lead to biomarker development. Innovation in plasma-circulating tumor cells, cell-free DNA, and functional imaging are expected to contribute significantly to the noninvasive lung cancer diagnostic pathway." @default.
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- W1967821841 date "2014-10-01" @default.
- W1967821841 modified "2023-10-16" @default.
- W1967821841 title "Development in the diagnostic lung cancer pathway: implication for treatment" @default.
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- W1967821841 doi "https://doi.org/10.2217/lmt.14.34" @default.
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