FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967821979> ?p ?o ?g. }

• W1967821979 endingPage "1884" @default.
• W1967821979 startingPage "1877" @default.
• W1967821979 abstract "There is evidence supporting that tumor necrosis factor receptor (TNFR)-signaling can induce production of beta-amyloid (Aβ) in the brain. Moreover, amyloid-induced toxicity has been shown to be dependent on TNFR-signaling. However, it is still unclear whether TNFRs are involved in the early stages of dementia.We analyzed soluble TNFR1 and TNFR2 levels in plasma and cerebrospinal fluid (CSF) at baseline in 137 patients with mild cognitive impairment (MCI) and 30 age-matched controls. The MCI patients were followed for 4-6 years with an incidence of Alzheimer's disease (AD) or vascular dementia (VaD) of 15% per year.The patients with MCI who subsequently developed these forms of dementias had higher levels of sTNFR1 and sTNFR2 in both CSF and plasma already at baseline when compared to age-matched controls (p<0.05). In the CSF of MCI subjects and controls the levels of both sTNFR1 and sTNFR2 correlated strongly with β-site APP-cleaving enzyme 1 (BACE1) activity (r(s)=0.53-0.68, p<0.01) and Aβ 40 levels (r(s)=0.59-0.71, p<0.001). Similarly, both sTNFRs were associated with Aβ 40 (r(s)=0.39-0.46, p<0.05) in plasma. Finally, the levels of both sTNFRs correlated with the axonal damage marker tau in the CSF of MCI subjects and controls (r(s)=0.57-0.83, p<0.001).TNFR-signaling might be involved in the early pathogenesis of AD and VaD, and could be associated with beta-amyloid metabolism." @default.
• W1967821979 created "2016-06-24" @default.
• W1967821979 creator A5001538826 @default.
• W1967821979 creator A5025313057 @default.
• W1967821979 creator A5049277633 @default.
• W1967821979 creator A5079766290 @default.
• W1967821979 creator A5080476940 @default.
• W1967821979 creator A5084055939 @default.
• W1967821979 date "2010-11-01" @default.
• W1967821979 modified "2023-10-16" @default.
• W1967821979 title "Soluble TNF receptors are associated with Aβ metabolism and conversion to dementia in subjects with mild cognitive impairment" @default.
• W1967821979 cites W1487068141 @default.
• W1967821979 cites W1618236677 @default.
• W1967821979 cites W1974924674 @default.
• W1967821979 cites W1976354184 @default.
• W1967821979 cites W1976445933 @default.
• W1967821979 cites W1978345359 @default.
• W1967821979 cites W1979221664 @default.
• W1967821979 cites W1986624196 @default.
• W1967821979 cites W1986830236 @default.
• W1967821979 cites W1992680479 @default.
• W1967821979 cites W2008128503 @default.
• W1967821979 cites W2011410834 @default.
• W1967821979 cites W2015919242 @default.
• W1967821979 cites W2026100040 @default.
• W1967821979 cites W2026292908 @default.
• W1967821979 cites W2028436804 @default.
• W1967821979 cites W2031236369 @default.
• W1967821979 cites W2040536037 @default.
• W1967821979 cites W2057858930 @default.
• W1967821979 cites W2062084653 @default.
• W1967821979 cites W2062968903 @default.
• W1967821979 cites W2067712423 @default.
• W1967821979 cites W2068477037 @default.
• W1967821979 cites W2073809577 @default.
• W1967821979 cites W2081826956 @default.
• W1967821979 cites W2084275222 @default.
• W1967821979 cites W2087574229 @default.
• W1967821979 cites W2088995267 @default.
• W1967821979 cites W2096277075 @default.
• W1967821979 cites W2105631420 @default.
• W1967821979 cites W2110081525 @default.
• W1967821979 cites W2112150247 @default.
• W1967821979 cites W2116784956 @default.
• W1967821979 cites W2117635180 @default.
• W1967821979 cites W2118634615 @default.
• W1967821979 cites W2118872783 @default.
• W1967821979 cites W2120648989 @default.
• W1967821979 cites W2124681501 @default.
• W1967821979 cites W2128948218 @default.
• W1967821979 cites W2130440272 @default.
• W1967821979 cites W2152860347 @default.
• W1967821979 cites W2156220037 @default.
• W1967821979 cites W2161737267 @default.
• W1967821979 cites W2164675880 @default.
• W1967821979 cites W231832547 @default.
• W1967821979 cites W4211156109 @default.
• W1967821979 doi "https://doi.org/10.1016/j.neurobiolaging.2008.10.012" @default.
• W1967821979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19070941" @default.
• W1967821979 hasPublicationYear "2010" @default.
• W1967821979 type Work @default.
• W1967821979 sameAs 1967821979 @default.
• W1967821979 citedByCount "95" @default.
• W1967821979 countsByYear W19678219792012 @default.
• W1967821979 countsByYear W19678219792013 @default.
• W1967821979 countsByYear W19678219792014 @default.
• W1967821979 countsByYear W19678219792015 @default.
• W1967821979 countsByYear W19678219792016 @default.
• W1967821979 countsByYear W19678219792017 @default.
• W1967821979 countsByYear W19678219792018 @default.
• W1967821979 countsByYear W19678219792019 @default.
• W1967821979 countsByYear W19678219792020 @default.
• W1967821979 countsByYear W19678219792021 @default.
• W1967821979 countsByYear W19678219792022 @default.
• W1967821979 countsByYear W19678219792023 @default.
• W1967821979 crossrefType "journal-article" @default.
• W1967821979 hasAuthorship W1967821979A5001538826 @default.
• W1967821979 hasAuthorship W1967821979A5025313057 @default.
• W1967821979 hasAuthorship W1967821979A5049277633 @default.
• W1967821979 hasAuthorship W1967821979A5079766290 @default.
• W1967821979 hasAuthorship W1967821979A5080476940 @default.
• W1967821979 hasAuthorship W1967821979A5084055939 @default.
• W1967821979 hasConcept C126322002 @default.
• W1967821979 hasConcept C134018914 @default.
• W1967821979 hasConcept C142724271 @default.
• W1967821979 hasConcept C15744967 @default.
• W1967821979 hasConcept C170493617 @default.
• W1967821979 hasConcept C17991360 @default.
• W1967821979 hasConcept C2776156579 @default.
• W1967821979 hasConcept C2777633098 @default.
• W1967821979 hasConcept C2777952318 @default.
• W1967821979 hasConcept C2779134260 @default.
• W1967821979 hasConcept C2779483572 @default.
• W1967821979 hasConcept C2779651940 @default.
• W1967821979 hasConcept C2780942790 @default.
• W1967821979 hasConcept C2984915365 @default.
• W1967821979 hasConcept C502032728 @default.
• W1967821979 hasConcept C71924100 @default.

• next