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• W1967838925 endingPage "773" @default.
• W1967838925 startingPage "755" @default.
• W1967838925 abstract "To evaluate functional neuronal compensation after partial damage to the nigrostriatal system, we lesioned rats unilaterally in the striatum with 6-hydroxydopamine. Five weeks later, cerebral perfusion was mapped at rest or during treadmill walking using [14C]-iodoantipyrine. Regional CBF-related tissue radioactivity (CBF-TR) was quantified by autoradiography and analyzed by statistical parametric mapping and region-of- interest analysis. Lesions were confirmed by tyrosine hydroxylase immunohistochemistry and changes in rotational locomotor activity. Functional compensations were bilateral and differed at rest and during treadmill walking. Consistent with the classic view of striatopallidal connections, CBF-TR of lesioned compared to sham-lesioned rats increased in the ipsilateral subthalamic nucleus (STN) and internal globus pallidus, and decreased in the striatum and external globus pallidus. Contrary to the classic view, CBF-TR increased in the ipsilateral ventral lateral, ventral anterior thalamus and motor cortex, as well as in the central medial thalamus, midline cerebellum, and contralateral STN. During walking, perfusion decreased in lesioned compared to sham-lesioned rats across the ipsilateral striato-pallidal-thalamic-cortical motor circuit. Compensatory increases were seen bilaterally in the ventromedial thalamus and red nucleus, in the contralateral STN, anterior substantia nigra, subiculum, motor cortex, and in midline cerebellum. Enhanced recruitment of associative sensory areas was noted cortically and subcortically. Future models of compensatory changes after nigrostriatal damage need to address the effects of increased neural activity by residual dopaminergic neurons, interhemispheric interactions and differences between resting and locomotor states. Identification of sites at which functional compensation occurs may define useful future targets for neurorehabilitative or neurorestorative interventions in Parkinson's disease." @default.
• W1967838925 created "2016-06-24" @default.
• W1967838925 creator A5011653784 @default.
• W1967838925 creator A5022450091 @default.
• W1967838925 creator A5044020631 @default.
• W1967838925 creator A5047836888 @default.
• W1967838925 creator A5089735251 @default.
• W1967838925 date "2007-07-01" @default.
• W1967838925 modified "2023-09-30" @default.
• W1967838925 title "Changes in brain functional activation during resting and locomotor states after unilateral nigrostriatal damage in rats" @default.
• W1967838925 cites W1501563538 @default.
• W1967838925 cites W1513126258 @default.
• W1967838925 cites W1567850969 @default.
• W1967838925 cites W1602611909 @default.
• W1967838925 cites W1777552195 @default.
• W1967838925 cites W1881391557 @default.
• W1967838925 cites W196181025 @default.
• W1967838925 cites W1964678635 @default.
• W1967838925 cites W1966123432 @default.
• W1967838925 cites W1967018739 @default.
• W1967838925 cites W1968352408 @default.
• W1967838925 cites W1968866375 @default.
• W1967838925 cites W1969923702 @default.
• W1967838925 cites W1971033359 @default.
• W1967838925 cites W1976782526 @default.
• W1967838925 cites W1979789394 @default.
• W1967838925 cites W1982827121 @default.
• W1967838925 cites W1985091985 @default.
• W1967838925 cites W1987619728 @default.
• W1967838925 cites W1987759867 @default.
• W1967838925 cites W1991502776 @default.
• W1967838925 cites W1993328141 @default.
• W1967838925 cites W1993818456 @default.
• W1967838925 cites W1995093354 @default.
• W1967838925 cites W1996254059 @default.
• W1967838925 cites W1997065612 @default.
• W1967838925 cites W1998592627 @default.
• W1967838925 cites W2002287054 @default.
• W1967838925 cites W2002314838 @default.
• W1967838925 cites W2002341696 @default.
• W1967838925 cites W2004996958 @default.
• W1967838925 cites W2005352680 @default.
• W1967838925 cites W2006722586 @default.
• W1967838925 cites W2008095538 @default.
• W1967838925 cites W2011386403 @default.
• W1967838925 cites W2012467167 @default.
• W1967838925 cites W2012920011 @default.
• W1967838925 cites W2014042367 @default.
• W1967838925 cites W2018050771 @default.
• W1967838925 cites W2021602283 @default.
• W1967838925 cites W2022784058 @default.
• W1967838925 cites W2023388136 @default.
• W1967838925 cites W2024486693 @default.
• W1967838925 cites W2025845183 @default.
• W1967838925 cites W2027274005 @default.
• W1967838925 cites W2027418337 @default.
• W1967838925 cites W2031170958 @default.
• W1967838925 cites W2031427673 @default.
• W1967838925 cites W2036812929 @default.
• W1967838925 cites W2038636807 @default.
• W1967838925 cites W2039096614 @default.
• W1967838925 cites W2051895625 @default.
• W1967838925 cites W2052142868 @default.
• W1967838925 cites W2056189993 @default.
• W1967838925 cites W2058489121 @default.
• W1967838925 cites W2059216763 @default.
• W1967838925 cites W2060023105 @default.
• W1967838925 cites W2060588252 @default.
• W1967838925 cites W2061553829 @default.
• W1967838925 cites W2064481951 @default.
• W1967838925 cites W2065000444 @default.
• W1967838925 cites W2066913836 @default.
• W1967838925 cites W2068008366 @default.
• W1967838925 cites W2068259028 @default.
• W1967838925 cites W2070446215 @default.
• W1967838925 cites W2073201795 @default.
• W1967838925 cites W2074402500 @default.
• W1967838925 cites W2076753818 @default.
• W1967838925 cites W2077258286 @default.
• W1967838925 cites W2078047158 @default.
• W1967838925 cites W2081299043 @default.
• W1967838925 cites W2086682944 @default.
• W1967838925 cites W2087547292 @default.
• W1967838925 cites W2090511519 @default.
• W1967838925 cites W2091227588 @default.
• W1967838925 cites W2092139956 @default.
• W1967838925 cites W2101036582 @default.
• W1967838925 cites W2102241733 @default.
• W1967838925 cites W2104199953 @default.
• W1967838925 cites W2106147981 @default.
• W1967838925 cites W2109765029 @default.
• W1967838925 cites W2113979027 @default.
• W1967838925 cites W2116766794 @default.
• W1967838925 cites W2128456781 @default.
• W1967838925 cites W2131124574 @default.
• W1967838925 cites W2131938193 @default.
• W1967838925 cites W2135215744 @default.
• W1967838925 cites W2138196107 @default.

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