FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967852077> ?p ?o ?g. }

• W1967852077 endingPage "52" @default.
• W1967852077 startingPage "31" @default.
• W1967852077 abstract "Persistent organochlorines such as chlordecone (CD), DDT, and DDT degradation products bioaccumulate in fish and potentially impair reproduction or development via estrogenic actions. We evaluated the estrogenicity of CD, o,p′-DDT, o,p′-DDE, and p,p′-DDE in juvenile rainbow trout by assessing their potential to induce vitellogenesis; estrogen-regulated hepatic synthesis of the yolk-protein precursor, vitellogenin (Vg). In order to compare the sensitivities of various markers of estrogen stimulation, trout were injected with 17β-estradiol (0–10 mg kg−1) on days 0 and 3 and were sampled on days 3–12. Estradiol (5 mg kg−1) increased plasma Vg (2400%; 640 μg 1−1), liver somatic index (200%) and hepatic cytosolic estrogen binding site levels (EBS, 300%) on day 6. These results suggested plasma Vg was the most sensitive marker of estrogen exposure. Chronic dietary exposure to CD (0.4 mg kg−1 day−1, 33 weeks) elevated plasma Vg (0.9 μg 1−1), but not hepatic EBS concentrations, and resulted in relatively high hepatic CD concentrations(16 μg g−1). The in vivo estrogenicity of DDT was examined by injecting trout at 14 day intervals with single or triplicate doses of o,p′-DDT, o,p′-DDE or p,p′-DDE (0, 5, 15 or 30 mg kg−1) and monitoring vitellogenesis 14 days after the final injection. Plasma Vg and hepatic EBS concentrations were significantly elevated by o,p′-DDT and o,p′-DDE (total dose 45 and 90 mg kg−1; 23–24 μg Vg 1−1) but not p,p′-DDE. Target organ doses were estimated by conducting a disposition study in which trout were injected with three doses of [14C]p,p′-DDE (30 mg kg−1), at 14 day intervals. Hepatic [14C]p,p′-DDE equivalent concentrations, 14 days after the final injection, averaged 14 μg g−1. Additionally, we evaluated the relative affinity of CD and DDT or DDE for trout hepatic EBS utilizing in vitro competitive binding assays. CD had relatively low affinity (1000-fold less than moxestrol, a synthetic estradiol) for trout hepatic BBS. o,p′-DDT and o,p′-DDE, but not p,p′-DDE, also exhibited low BBS affinity (approximately 156000-fold less than moxestrol). Collectively, these results indicated that CD, o,p′-DDT and o,p′-DDE were weakly estrogenic in juvenile trout." @default.
• W1967852077 created "2016-06-24" @default.
• W1967852077 creator A5050727841 @default.
• W1967852077 creator A5071555021 @default.
• W1967852077 date "1996-11-01" @default.
• W1967852077 modified "2023-09-30" @default.
• W1967852077 title "Estrogenic activity of chlordecone, o,p′-DDT and o,p′-DDE in juvenile rainbow trout: induction of vitellogenesis and interaction with hepatic estrogen binding sites" @default.
• W1967852077 cites W1775749144 @default.
• W1967852077 cites W1906197854 @default.
• W1967852077 cites W1966534090 @default.
• W1967852077 cites W1967147169 @default.
• W1967852077 cites W1980867160 @default.
• W1967852077 cites W1982885726 @default.
• W1967852077 cites W1983649348 @default.
• W1967852077 cites W1987255586 @default.
• W1967852077 cites W1988330535 @default.
• W1967852077 cites W1990609161 @default.
• W1967852077 cites W1992793485 @default.
• W1967852077 cites W1992989286 @default.
• W1967852077 cites W1996620992 @default.
• W1967852077 cites W1997986452 @default.
• W1967852077 cites W2001266451 @default.
• W1967852077 cites W2009040345 @default.
• W1967852077 cites W2020786888 @default.
• W1967852077 cites W2023839461 @default.
• W1967852077 cites W2027157632 @default.
• W1967852077 cites W2029409956 @default.
• W1967852077 cites W2037024562 @default.
• W1967852077 cites W2040664203 @default.
• W1967852077 cites W2045916783 @default.
• W1967852077 cites W2058540606 @default.
• W1967852077 cites W2061564482 @default.
• W1967852077 cites W2066898685 @default.
• W1967852077 cites W2068640728 @default.
• W1967852077 cites W2068892722 @default.
• W1967852077 cites W2073202847 @default.
• W1967852077 cites W2073874548 @default.
• W1967852077 cites W2082220494 @default.
• W1967852077 cites W2090778700 @default.
• W1967852077 cites W2091424906 @default.
• W1967852077 cites W2091984768 @default.
• W1967852077 cites W2099303192 @default.
• W1967852077 cites W2101287457 @default.
• W1967852077 cites W2105779159 @default.
• W1967852077 cites W2132395936 @default.
• W1967852077 cites W2136695719 @default.
• W1967852077 cites W2136948022 @default.
• W1967852077 cites W2248542 @default.
• W1967852077 cites W4254093939 @default.
• W1967852077 cites W71209477 @default.
• W1967852077 doi "https://doi.org/10.1016/s0166-445x(96)00799-0" @default.
• W1967852077 hasPublicationYear "1996" @default.
• W1967852077 type Work @default.
• W1967852077 sameAs 1967852077 @default.
• W1967852077 citedByCount "158" @default.
• W1967852077 countsByYear W19678520772012 @default.
• W1967852077 countsByYear W19678520772013 @default.
• W1967852077 countsByYear W19678520772014 @default.
• W1967852077 countsByYear W19678520772015 @default.
• W1967852077 countsByYear W19678520772016 @default.
• W1967852077 countsByYear W19678520772017 @default.
• W1967852077 countsByYear W19678520772018 @default.
• W1967852077 countsByYear W19678520772019 @default.
• W1967852077 countsByYear W19678520772020 @default.
• W1967852077 countsByYear W19678520772022 @default.
• W1967852077 countsByYear W19678520772023 @default.
• W1967852077 crossrefType "journal-article" @default.
• W1967852077 hasAuthorship W1967852077A5050727841 @default.
• W1967852077 hasAuthorship W1967852077A5071555021 @default.
• W1967852077 hasConcept C104317684 @default.
• W1967852077 hasConcept C126322002 @default.
• W1967852077 hasConcept C134018914 @default.
• W1967852077 hasConcept C185592680 @default.
• W1967852077 hasConcept C196843134 @default.
• W1967852077 hasConcept C2776690073 @default.
• W1967852077 hasConcept C2777164284 @default.
• W1967852077 hasConcept C2779078696 @default.
• W1967852077 hasConcept C2779363728 @default.
• W1967852077 hasConcept C2909208804 @default.
• W1967852077 hasConcept C2994167347 @default.
• W1967852077 hasConcept C505870484 @default.
• W1967852077 hasConcept C55493867 @default.
• W1967852077 hasConcept C56366318 @default.
• W1967852077 hasConcept C71924100 @default.
• W1967852077 hasConcept C86803240 @default.
• W1967852077 hasConcept C95444343 @default.
• W1967852077 hasConceptScore W1967852077C104317684 @default.
• W1967852077 hasConceptScore W1967852077C126322002 @default.
• W1967852077 hasConceptScore W1967852077C134018914 @default.
• W1967852077 hasConceptScore W1967852077C185592680 @default.
• W1967852077 hasConceptScore W1967852077C196843134 @default.
• W1967852077 hasConceptScore W1967852077C2776690073 @default.
• W1967852077 hasConceptScore W1967852077C2777164284 @default.
• W1967852077 hasConceptScore W1967852077C2779078696 @default.
• W1967852077 hasConceptScore W1967852077C2779363728 @default.
• W1967852077 hasConceptScore W1967852077C2909208804 @default.
• W1967852077 hasConceptScore W1967852077C2994167347 @default.
• W1967852077 hasConceptScore W1967852077C505870484 @default.

• next