FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967859158> ?p ?o ?g. }

• W1967859158 endingPage "925" @default.
• W1967859158 startingPage "921" @default.
• W1967859158 abstract "The smt locus of Synechococcus PCC 7942 contains a metal-regulated gene (smtA), which encodes a class II metallothionein, and a divergently transcribed gene, smtB, which encodes a repressor of smtA transcription. Regions containing cis-acting eiements required for efficient induction, and required for smtB-dependent repression, of the smtA operator-promoter were identified. Specific interactions between proteins extracted from Synechococcus PCC 7942 and defined regions surrounding the smtA operator-promoter were detected by electrophoretic mobility shift assays. Three metallothionein operator-promoter associated complexes were identified, one of which (MAC1) showed Zn-dependent dissociation and involved a region of DNA immediately upstream of smtA. Treatment with Zn-chelators facilitated re-association of MAC1 in vitro. MAC1 was not observed in extracts from smt deficient mutants but was restored in extracts from mutants complemented with a plasmid borne smtB. SmtB is thus required for the formation of a Zn-responsive complex with the smt operator-promoter and based upon the predicted structure of SmtB we propose direct SmtB-DNA interaction exerting metalion inducibie negative control." @default.
• W1967859158 created "2016-06-24" @default.
• W1967859158 creator A5019649677 @default.
• W1967859158 creator A5058467039 @default.
• W1967859158 creator A5072432565 @default.
• W1967859158 creator A5085729637 @default.
• W1967859158 date "1993-01-01" @default.
• W1967859158 modified "2023-09-27" @default.
• W1967859158 title "SmtB is a metal-dependent repressor of the cyanobacterial metallothionein gene<i>smtA</i>: identification of a Zn inhibited DNA-protein complex" @default.
• W1967859158 cites W1490820480 @default.
• W1967859158 cites W1937337525 @default.
• W1967859158 cites W1978491890 @default.
• W1967859158 cites W1985943254 @default.
• W1967859158 cites W1987498682 @default.
• W1967859158 cites W2009310436 @default.
• W1967859158 cites W2012627508 @default.
• W1967859158 cites W2037748263 @default.
• W1967859158 cites W2040350531 @default.
• W1967859158 cites W2046272616 @default.
• W1967859158 cites W2050692858 @default.
• W1967859158 cites W2053402793 @default.
• W1967859158 cites W2059495513 @default.
• W1967859158 cites W2063832119 @default.
• W1967859158 cites W2104859115 @default.
• W1967859158 cites W2120485726 @default.
• W1967859158 doi "https://doi.org/10.1093/nar/21.4.921" @default.
• W1967859158 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/309225" @default.
• W1967859158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8451191" @default.
• W1967859158 hasPublicationYear "1993" @default.
• W1967859158 type Work @default.
• W1967859158 sameAs 1967859158 @default.
• W1967859158 citedByCount "154" @default.
• W1967859158 countsByYear W19678591582012 @default.
• W1967859158 countsByYear W19678591582013 @default.
• W1967859158 countsByYear W19678591582014 @default.
• W1967859158 countsByYear W19678591582015 @default.
• W1967859158 countsByYear W19678591582016 @default.
• W1967859158 countsByYear W19678591582017 @default.
• W1967859158 countsByYear W19678591582018 @default.
• W1967859158 countsByYear W19678591582019 @default.
• W1967859158 countsByYear W19678591582020 @default.
• W1967859158 countsByYear W19678591582021 @default.
• W1967859158 countsByYear W19678591582022 @default.
• W1967859158 countsByYear W19678591582023 @default.
• W1967859158 crossrefType "journal-article" @default.
• W1967859158 hasAuthorship W1967859158A5019649677 @default.
• W1967859158 hasAuthorship W1967859158A5058467039 @default.
• W1967859158 hasAuthorship W1967859158A5072432565 @default.
• W1967859158 hasAuthorship W1967859158A5085729637 @default.
• W1967859158 hasBestOaLocation W19678591582 @default.
• W1967859158 hasConcept C104317684 @default.
• W1967859158 hasConcept C138885662 @default.
• W1967859158 hasConcept C143065580 @default.
• W1967859158 hasConcept C153911025 @default.
• W1967859158 hasConcept C158448853 @default.
• W1967859158 hasConcept C17020691 @default.
• W1967859158 hasConcept C179926584 @default.
• W1967859158 hasConcept C20719415 @default.
• W1967859158 hasConcept C22744801 @default.
• W1967859158 hasConcept C41895202 @default.
• W1967859158 hasConcept C54355233 @default.
• W1967859158 hasConcept C552990157 @default.
• W1967859158 hasConcept C86339819 @default.
• W1967859158 hasConcept C86803240 @default.
• W1967859158 hasConceptScore W1967859158C104317684 @default.
• W1967859158 hasConceptScore W1967859158C138885662 @default.
• W1967859158 hasConceptScore W1967859158C143065580 @default.
• W1967859158 hasConceptScore W1967859158C153911025 @default.
• W1967859158 hasConceptScore W1967859158C158448853 @default.
• W1967859158 hasConceptScore W1967859158C17020691 @default.
• W1967859158 hasConceptScore W1967859158C179926584 @default.
• W1967859158 hasConceptScore W1967859158C20719415 @default.
• W1967859158 hasConceptScore W1967859158C22744801 @default.
• W1967859158 hasConceptScore W1967859158C41895202 @default.
• W1967859158 hasConceptScore W1967859158C54355233 @default.
• W1967859158 hasConceptScore W1967859158C552990157 @default.
• W1967859158 hasConceptScore W1967859158C86339819 @default.
• W1967859158 hasConceptScore W1967859158C86803240 @default.
• W1967859158 hasIssue "4" @default.
• W1967859158 hasLocation W19678591581 @default.
• W1967859158 hasLocation W19678591582 @default.
• W1967859158 hasLocation W19678591583 @default.
• W1967859158 hasLocation W19678591584 @default.
• W1967859158 hasOpenAccess W1967859158 @default.
• W1967859158 hasPrimaryLocation W19678591581 @default.
• W1967859158 hasRelatedWork W1571771606 @default.
• W1967859158 hasRelatedWork W1968976175 @default.
• W1967859158 hasRelatedWork W2001204456 @default.
• W1967859158 hasRelatedWork W2078436959 @default.
• W1967859158 hasRelatedWork W2111958127 @default.
• W1967859158 hasRelatedWork W2117110650 @default.
• W1967859158 hasRelatedWork W2414030161 @default.
• W1967859158 hasRelatedWork W2524850911 @default.
• W1967859158 hasRelatedWork W2620737981 @default.
• W1967859158 hasRelatedWork W3215086467 @default.
• W1967859158 hasVolume "21" @default.
• W1967859158 isParatext "false" @default.
• W1967859158 isRetracted "false" @default.

• next