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• W1967865536 abstract "Pyrus bretschneideri Rehd., as a pharmaceutical supplement, is widely used in northern China to treat respiratory diseases. Our previous studies showed the ethanol extract of P. bretschneideri had significant anti-inflammatory activity. To isolate and identify the active ingredients, the ethanol extract was separated into petroleum ether, ethyl acetate, n-butanol, and aqueous fractions. The bioactivity of each fraction was investigated using an in vivo model. Results showed that the ethyl acetate fraction exhibited the strongest anti-inflammatory effect. Subsequently, this fraction was subjected to separation and purification using silica gel column chromatography, C18-ODS, and recrystallization, leading to two sterols and two triterpenes, which were identified as β-sitosterol, daucosterol, oleanolic acid, and ursolic acid. Moreover, all of the isolated compounds could significantly inhibit the ear edema induced by xylene. These results indicated that P. bretschneideri had good anti-inflammatory effects and the constituents β-sitosterol, daucosterol, oleanolic acid, and ursolic acid might well account for it." @default.
• W1967865536 created "2016-06-24" @default.
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• W1967865536 date "2010-07-30" @default.
• W1967865536 modified "2023-10-18" @default.
• W1967865536 title "Evaluation of the <i>in Vivo</i> Anti-inflammatory Effects of Extracts from Pyrus bretschneideri Rehd." @default.
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• W1967865536 doi "https://doi.org/10.1021/jf101390q" @default.
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