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- W1967874015 abstract "We have cloned, from the genome of HeLa cells, related 1.8-kb highly repetitive EcoRI satellite II (and III) DNA family members that displayed a high degree of TaqI and HinfI variations. Comparative sequence analysis of these cloned DNAs suggests that highly repetitive satellite DNAs may have evolved and diversified from the rapid amplification of a pentameric unit (5′ TTCCA 3′), by processes including random and non-random mutations. Base conservation, as well as mutational hotspots, were found associated with these related satellite II and III DNAs. The accumulation of C to G transversions within the pentamers, generating TaqI and HinfI sites, as well as C to T transitions at CpN dinucleotides, appear to be responsible for much of the microheterogeneity observed between related satellite II and III DNA family members.Key words: repetitive DNAs, heterochromatin, satellite DNAs, DNA sequence." @default.
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- W1967874015 date "1993-04-01" @default.
- W1967874015 modified "2023-09-24" @default.
- W1967874015 title "Sequence analysis of cloned human satellite DNAs reveals nonrandom variations" @default.
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- W1967874015 doi "https://doi.org/10.1139/g93-046" @default.
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