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• W1967874261 abstract "The specific binding characteristics of αvβ3 integrins with an arginine-glycine-aspartic-acid (RGD) containing fluorescently labeled cyclic peptide is investigated with capillary electrophoresis-frontal analysis method. The new algorithm used to calculate the binding constants and binding stoichiometry was derived without the assumptions made in the commonly used Scatchard Plot method, thus enabling the determination of specific binding parameters in the presence of nonspecific binding. The αvβ3 integrin, a membrane protein, was studied in solution, without the need of immobilization or any other kind of modification. An RGD containing fluorescently labeled cyclic pentapeptide is used as the ligand with both specific and nonspecific binding characteristics, and an arginine-alanine-aspartic-acid (RAD) containing peptide is used as the control for nonspecific binding. While a typical specific binding isotherm has a shape of a rectangular hyperbola, a nonspecific binding isotherm is linear in the same ligand concentration region. A 1:2 specific binding stoichiometry was revealed with the second binding having a similar affinity compared to the first binding event." @default.
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• W1967874261 date "2008-03-27" @default.
• W1967874261 modified "2023-09-25" @default.
• W1967874261 title "Capillary Electrophoresis Frontal Analysis for Characterization of α_vβ₃ Integrin Binding Interactions" @default.
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• W1967874261 doi "https://doi.org/10.1021/ac701604a" @default.
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