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- W1967875433 abstract "Abstract 1. During fatty acid oxidation by rat liver mitochondria, the rate of β-oxidation is dependent on the relative amounts of substrate and mitochondrial protein, on the energy state of the mitochondria, on the chain length and the number of double bonds of the fatty acid and on the concentration of various compounds in the reaction medium ( l -carnitine, CoASH, hexokinase, albumin). 2. The rate of β-oxidation of long-chain fatty acids decreases when the ratio of albumin over fatty acid is increased. This effect is most marked in the absence of added carnitine. 3. Addition of excess hexokinase decreases the rate of β-oxidation in the presence of added carnitine. 4. Maximal rates of β-oxidation are observed with octanoate and decanoate (40–60 nmoles acetyl-CoA/min per mg mitochondrial protein at 25 °C). 5. Odd-numbered fatty acids are oxidized at a much lower rate than the even-numbered homologues. In a low-energy state propionyl-CoA accumulates; in a high-energy state in the presence of bicarbonate, Krebs-cycle intermediates accumulate. 6. l -Carnitine enhances the rate of β-oxidation of all fatty acids except butyrate. The stimulatory effect is most pronounced with odd-numbered and with long-chain fatty acids. 7. In the absence of added carnitine the rate of β-oxidation of long-chain fatty acids decreases with the chain length and increases with the number of double bonds. It is suggested that the solubility of the long-chain fatty acids in the aqueous medium is the rate-limiting factor under these conditions. 8. In the presence of carnitine and albumin, palmitate, oleate, linoleate and linolenate are all oxidized at about the same rate (25–30 nmoles/min per mg protein at 25 °C). 9. Propionyl-CoA is not formed as an intermediate during oxidation of unsaturated fatty acids." @default.
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- W1967875433 date "1974-07-01" @default.
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- W1967875433 title "Ketogenesis in isolated rat liver mitochondria. II. Factors affecting the rate of β-oxidation" @default.
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- W1967875433 doi "https://doi.org/10.1016/0005-2728(74)90110-8" @default.
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