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- W1967877552 abstract "1 The use of the cytoplasmic enzyme, alpha glutathione s-transferase (α-GST) as an early index of carbon tetrachloride (CCl 4 ) toxicity in the rat was investigated and compared with a standard enzyme marker, aspartate aminotransferase (AST). The hepatotoxic effects of CCl 4 in the rat were determined in a time and dose-response study. 2 Following CCl 4 exposure, α-GST release was shown to be an earlier and more sensitive biomarker of hepatotoxicity than AST. 3 Significant increases in α-GST were detected 2 h after CCl 4 exposure. Using the enzyme marker AST, this early hepatotoxic injury went undetected. At 6 and 16 h, α-GST was also a more sensitive indicator of hepatotoxicity than AST. 4 α-GST release was significantly increased at a dose of 5 μl/kg, the lowest concentration of CCl 4 administered and clearly responded in a dose-dependent manner with increasing doses of CCl 4 . In contrast, release of AST did not reach statistical significance until a dose of 25 μl/kg. 5 Thus, these findings indicate that α-GST is a more sensitive and more accurate reflector of CCl 4 induced hepatotoxicity than AST." @default.
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- W1967877552 date "1997-03-01" @default.
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- W1967877552 title "α-glutathione s-transferase (α-GST) release, an early indicator of carbon tetrachloride hepatotoxicity in the rat" @default.
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- W1967877552 doi "https://doi.org/10.1177/096032719701600304" @default.
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