FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967877786> ?p ?o ?g. }

• W1967877786 endingPage "241" @default.
• W1967877786 startingPage "238" @default.
• W1967877786 abstract "The concept of fetal programming of disease in later life after intrauterine growth restriction (IUGR) has opened a potential new perspective on the treatment and prevention of arterial hypertension. Numerous large studies have recently confirmed the relationship between low birth weight and raised blood pressure. Hyperalimentation after birth appears to add to the risk of higher blood pressure later in life. However, there is still a controversy and clear intervention studies have not yet been possible. Therefore, the gain of knowledge about the underlying mechanisms of fetal programming is of utmost importance.Two major groups of mechanisms may be identified: renal and extrarenal mechanisms. Renal mechanisms include the reduction of nephron number, which is encountered in patients and animals with low birth weight. According to the so-called Brenner hypothesis, this may lead to increased arterial blood pressure. Another important renal system is the renin-angiotensin-aldosterone system, which appears to be more active on a number of levels in low birth weight individuals. Finally, there is the conversion of cortisol to inactive cortisone by the 11beta-hydroxysteroid dehydrogenase in distal tubule cells, which is reduced after intrauterine growth restriction. This enables a more powerful activation of mineralocorticoid receptors by cortisol. Extrarenal mechanisms include alterations in vascular structure (primary and secondary), increased activity of the sympathetic nerve system, and maybe most interestingly, an impairment of endothelial function. The latter is at least partially caused by an inactivation of nitric oxide by an excess of free oxygen radicals. In summary, mechanisms of fetal programming are only in the process of being revealed, and research has to focus on finding the key mechanism that might allow for successful intervention." @default.
• W1967877786 created "2016-06-24" @default.
• W1967877786 creator A5044454219 @default.
• W1967877786 date "2009-02-27" @default.
• W1967877786 modified "2023-10-10" @default.
• W1967877786 title "Renal and extrarenal mechanisms of perinatal programming after intrauterine growth restriction" @default.
• W1967877786 cites W1966249962 @default.
• W1967877786 cites W1968272943 @default.
• W1967877786 cites W1983374783 @default.
• W1967877786 cites W1984191137 @default.
• W1967877786 cites W1985891842 @default.
• W1967877786 cites W1989125185 @default.
• W1967877786 cites W1993681932 @default.
• W1967877786 cites W2014627766 @default.
• W1967877786 cites W2014631999 @default.
• W1967877786 cites W2032972908 @default.
• W1967877786 cites W2033263229 @default.
• W1967877786 cites W2035038939 @default.
• W1967877786 cites W2038479789 @default.
• W1967877786 cites W2040103319 @default.
• W1967877786 cites W2057140302 @default.
• W1967877786 cites W2065786310 @default.
• W1967877786 cites W2068960879 @default.
• W1967877786 cites W2071680557 @default.
• W1967877786 cites W2081523875 @default.
• W1967877786 cites W2083691099 @default.
• W1967877786 cites W2094433930 @default.
• W1967877786 cites W2095021180 @default.
• W1967877786 cites W2102788691 @default.
• W1967877786 cites W2104479115 @default.
• W1967877786 cites W2104504043 @default.
• W1967877786 cites W2114883889 @default.
• W1967877786 cites W2118969927 @default.
• W1967877786 cites W2121917420 @default.
• W1967877786 cites W2123951423 @default.
• W1967877786 cites W2126189493 @default.
• W1967877786 cites W2129541442 @default.
• W1967877786 cites W2138242595 @default.
• W1967877786 cites W2139020475 @default.
• W1967877786 cites W2142062298 @default.
• W1967877786 cites W2143578667 @default.
• W1967877786 cites W2145821301 @default.
• W1967877786 cites W2160704068 @default.
• W1967877786 cites W2166194564 @default.
• W1967877786 cites W2333675913 @default.
• W1967877786 cites W4210953733 @default.
• W1967877786 cites W4238844867 @default.
• W1967877786 doi "https://doi.org/10.1038/hr.2009.4" @default.
• W1967877786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19262494" @default.
• W1967877786 hasPublicationYear "2009" @default.
• W1967877786 type Work @default.
• W1967877786 sameAs 1967877786 @default.
• W1967877786 citedByCount "26" @default.
• W1967877786 countsByYear W19678777862012 @default.
• W1967877786 countsByYear W19678777862013 @default.
• W1967877786 countsByYear W19678777862014 @default.
• W1967877786 countsByYear W19678777862015 @default.
• W1967877786 countsByYear W19678777862016 @default.
• W1967877786 countsByYear W19678777862019 @default.
• W1967877786 crossrefType "journal-article" @default.
• W1967877786 hasAuthorship W1967877786A5044454219 @default.
• W1967877786 hasBestOaLocation W19678777861 @default.
• W1967877786 hasConcept C126322002 @default.
• W1967877786 hasConcept C134018914 @default.
• W1967877786 hasConcept C159641895 @default.
• W1967877786 hasConcept C172680121 @default.
• W1967877786 hasConcept C2776069600 @default.
• W1967877786 hasConcept C2776886772 @default.
• W1967877786 hasConcept C2776953305 @default.
• W1967877786 hasConcept C2778525890 @default.
• W1967877786 hasConcept C2778780700 @default.
• W1967877786 hasConcept C2779083892 @default.
• W1967877786 hasConcept C2779234561 @default.
• W1967877786 hasConcept C2781231759 @default.
• W1967877786 hasConcept C54355233 @default.
• W1967877786 hasConcept C71924100 @default.
• W1967877786 hasConcept C84393581 @default.
• W1967877786 hasConcept C86803240 @default.
• W1967877786 hasConceptScore W1967877786C126322002 @default.
• W1967877786 hasConceptScore W1967877786C134018914 @default.
• W1967877786 hasConceptScore W1967877786C159641895 @default.
• W1967877786 hasConceptScore W1967877786C172680121 @default.
• W1967877786 hasConceptScore W1967877786C2776069600 @default.
• W1967877786 hasConceptScore W1967877786C2776886772 @default.
• W1967877786 hasConceptScore W1967877786C2776953305 @default.
• W1967877786 hasConceptScore W1967877786C2778525890 @default.
• W1967877786 hasConceptScore W1967877786C2778780700 @default.
• W1967877786 hasConceptScore W1967877786C2779083892 @default.
• W1967877786 hasConceptScore W1967877786C2779234561 @default.
• W1967877786 hasConceptScore W1967877786C2781231759 @default.
• W1967877786 hasConceptScore W1967877786C54355233 @default.
• W1967877786 hasConceptScore W1967877786C71924100 @default.
• W1967877786 hasConceptScore W1967877786C84393581 @default.
• W1967877786 hasConceptScore W1967877786C86803240 @default.
• W1967877786 hasIssue "4" @default.
• W1967877786 hasLocation W19678777861 @default.
• W1967877786 hasLocation W19678777862 @default.
• W1967877786 hasOpenAccess W1967877786 @default.

• next