FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967907511> ?p ?o ?g. }

• W1967907511 endingPage "380" @default.
• W1967907511 startingPage "372" @default.
• W1967907511 abstract "Summary The aim of this study was to assess the effect of Adalimumab on different immune parameters in patients with RA. Adalimumab was administered (40 mg every other week for 26 weeks) to eight patients with RA that were refractory to conventional drug therapy. Peripheral blood samples were obtained at days 0, 15 and 180 of Adalimumab therapy, and the following immune parameters were assessed: Number, phenotype, and function of regulatory T lymphocytes. The induction of apoptosis of immune cells and the in vitro and in vivo reactivity towards M. tuberculosis were also analysed. All patients responded to Adalimumab (ACR response 50–70), and a modest but significant increase in the number and function of regulatory T cells was observed at day 15 of anti-TNF-α therapy. In addition, an increased percent of apoptotic cells was detected in the peripheral blood at day 15 of Adalimumab therapy. Unexpectedly, most of these effects were not further observed at day 180. However, two patients showed a persistent and marked reduction in the reactivity to M. tuberculosis. Although we have found that Adalimumab affects the number and function of regulatory T lymphocytes, and the apoptosis of immune cells, these effects are transient and its possible causal relationship with the therapeutic activity of this biological agent remains to be determined. Nevertheless, the down-regulatory effect of Adalimumab on the reactivity to M. tuberculosis could be related to an enhanced risk of tuberculosis reactivation." @default.
• W1967907511 created "2016-06-24" @default.
• W1967907511 creator A5005157766 @default.
• W1967907511 creator A5008101322 @default.
• W1967907511 creator A5014671357 @default.
• W1967907511 creator A5017946524 @default.
• W1967907511 creator A5032780650 @default.
• W1967907511 creator A5033468824 @default.
• W1967907511 creator A5066618167 @default.
• W1967907511 creator A5071659815 @default.
• W1967907511 creator A5082767353 @default.
• W1967907511 date "2005-06-16" @default.
• W1967907511 modified "2023-09-27" @default.
• W1967907511 title "Immune effects of therapy with Adalimumab in patients with rheumatoid arthritis" @default.
• W1967907511 cites W1534409678 @default.
• W1967907511 cites W1560277370 @default.
• W1967907511 cites W1560623534 @default.
• W1967907511 cites W1611284225 @default.
• W1967907511 cites W1666257151 @default.
• W1967907511 cites W1922746363 @default.
• W1967907511 cites W1966812104 @default.
• W1967907511 cites W1969374521 @default.
• W1967907511 cites W1976809749 @default.
• W1967907511 cites W1978117435 @default.
• W1967907511 cites W1996087599 @default.
• W1967907511 cites W2006697482 @default.
• W1967907511 cites W2007673642 @default.
• W1967907511 cites W2011319298 @default.
• W1967907511 cites W2013829686 @default.
• W1967907511 cites W2016341903 @default.
• W1967907511 cites W2033299724 @default.
• W1967907511 cites W2036218409 @default.
• W1967907511 cites W2039597867 @default.
• W1967907511 cites W2045236396 @default.
• W1967907511 cites W2048488222 @default.
• W1967907511 cites W2057132697 @default.
• W1967907511 cites W2058064986 @default.
• W1967907511 cites W2072829987 @default.
• W1967907511 cites W2074438676 @default.
• W1967907511 cites W2079039349 @default.
• W1967907511 cites W2086721113 @default.
• W1967907511 cites W2093383759 @default.
• W1967907511 cites W2103711360 @default.
• W1967907511 cites W2114004413 @default.
• W1967907511 cites W2115880102 @default.
• W1967907511 cites W2118268169 @default.
• W1967907511 cites W2124621398 @default.
• W1967907511 cites W2133782563 @default.
• W1967907511 cites W2135280067 @default.
• W1967907511 cites W2137208120 @default.
• W1967907511 cites W2141280116 @default.
• W1967907511 cites W2152348310 @default.
• W1967907511 cites W2158329969 @default.
• W1967907511 cites W2161153023 @default.
• W1967907511 cites W2171877287 @default.
• W1967907511 doi "https://doi.org/10.1111/j.1365-2249.2005.02859.x" @default.
• W1967907511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1809428" @default.
• W1967907511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15996202" @default.
• W1967907511 hasPublicationYear "2005" @default.
• W1967907511 type Work @default.
• W1967907511 sameAs 1967907511 @default.
• W1967907511 citedByCount "60" @default.
• W1967907511 countsByYear W19679075112012 @default.
• W1967907511 countsByYear W19679075112013 @default.
• W1967907511 countsByYear W19679075112015 @default.
• W1967907511 countsByYear W19679075112016 @default.
• W1967907511 countsByYear W19679075112018 @default.
• W1967907511 countsByYear W19679075112019 @default.
• W1967907511 countsByYear W19679075112021 @default.
• W1967907511 countsByYear W19679075112022 @default.
• W1967907511 crossrefType "journal-article" @default.
• W1967907511 hasAuthorship W1967907511A5005157766 @default.
• W1967907511 hasAuthorship W1967907511A5008101322 @default.
• W1967907511 hasAuthorship W1967907511A5014671357 @default.
• W1967907511 hasAuthorship W1967907511A5017946524 @default.
• W1967907511 hasAuthorship W1967907511A5032780650 @default.
• W1967907511 hasAuthorship W1967907511A5033468824 @default.
• W1967907511 hasAuthorship W1967907511A5066618167 @default.
• W1967907511 hasAuthorship W1967907511A5071659815 @default.
• W1967907511 hasAuthorship W1967907511A5082767353 @default.
• W1967907511 hasBestOaLocation W19679075112 @default.
• W1967907511 hasConcept C126322002 @default.
• W1967907511 hasConcept C142724271 @default.
• W1967907511 hasConcept C203014093 @default.
• W1967907511 hasConcept C2777575956 @default.
• W1967907511 hasConcept C2780132546 @default.
• W1967907511 hasConcept C2781069245 @default.
• W1967907511 hasConcept C71924100 @default.
• W1967907511 hasConcept C8891405 @default.
• W1967907511 hasConceptScore W1967907511C126322002 @default.
• W1967907511 hasConceptScore W1967907511C142724271 @default.
• W1967907511 hasConceptScore W1967907511C203014093 @default.
• W1967907511 hasConceptScore W1967907511C2777575956 @default.
• W1967907511 hasConceptScore W1967907511C2780132546 @default.
• W1967907511 hasConceptScore W1967907511C2781069245 @default.
• W1967907511 hasConceptScore W1967907511C71924100 @default.
• W1967907511 hasConceptScore W1967907511C8891405 @default.
• W1967907511 hasIssue "2" @default.

• next