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• W1967909138 abstract "1. Simultaneous catheterization of the left and right heart was performed thirty-three times in twenty-six individuals; three with normal cardiovascular systems; twelve with mitral stenosis; and eleven with aortic stenosis. 2. Cardiac output and pressure gradients were obtained simultaneously and the orifice size calculated. 3. The constant physiologic abnormality in mitral stenosis was the presence of a ventricular filling pressure gradient. The latter alone did not reflect the degree of mitral obstruction. The gradient was influenced by the rate of blood flow across the mitral valve. The height of the pulmonary artery pressure was not necessarily a measure of the degree of stenosis. When the degree of mitral obstruction and pulmonary vascular resistance were constant, the rate of blood flow varied with the height of the pulmonary artery pressure. When the degree of mitral obstruction and rate of blood flow across the valve were constant, the height of the pulmonary artery pressure reflected the degree of pulmonary vascular resistance. 4. Aortic stenosis was accompanied constantly by a pressure gradient across the aortic valve during ventricular systole. The systemic blood flow was generally reduced and was a function of the pressure gradient and degree of aortic obstruction. The gradient alone was not an accurate measure of the degree of obstruction. In aortic stenosis, the pressure-volume elasticity relationships of the left ventricle are altered as a result of hypertrophy reflecting itself in elevation of the end-diastolic pressure. This did not correlate with clinical left ventricular failure. Total left ventricular work was one and one-half to two times normal. Giant “a” waves were characteristically observed in the left atrial pressure tracings. 5. Estimation of the degree of obstruction at the mitral and aortic valves requires a knowledge of the pressure-flow relationships. 6. The applicability of combined heart catheterization in evaluating patients for cardiac surgery and surgical techniques for correction of stenotic valvular lesions is demonstrated." @default.
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• W1967909138 date "1957-04-01" @default.
• W1967909138 modified "2023-09-27" @default.
• W1967909138 title "Simultaneous (combined) catheterization of the left and right heart" @default.
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• W1967909138 doi "https://doi.org/10.1016/0002-8703(57)90366-6" @default.
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