Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967924344> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1967924344 abstract "1. The interactions of alpha-bungarotoxin or tubocurarine with the neuromuscular block and endplate depolarization induced by succinylcholine (SCh) in the phrenic nerve-diaphragm preparation of mice were studied in order to elucidate the role of depolarization by SCh in the neuromuscular blockade. 2. The SCh concentrations required to depress the indirect twitch response by 20% and the evoked endplate potential in cut muscle preparations by 80% were 10 microm and 6 microM, respectively, while only 2 microM SCh was needed to induce maximal endplate depolarization from -80 mV to about -60 mV. 3. SCh blocked the neuromuscular transmission synergistically with either alpha-bungarotoxin or tubocurarine. There was an initial partial reversal of the neuromuscular inhibition caused by tubocurarine, but not that by alpha-bungarotoxin. 4. alpha-Bungarotoxin (0.025 microM) antagonized SCh (10 microM)-induced depolarization more effectively than it depressed miniature endplate potentials and the antagonism was insurmountable by increasing SCh concentration. By contrast, tubocurarine preferentially depressed miniature endplate potentials and antagonized SCh-depolarization competitively. 5. The above difference was attributed to the irreversible nature of alpha-bungarotoxin binding to acetylcholine receptors, to the slow diffusion of the toxin molecule into the synaptic cleft and thus to the more rapid binding with perijunctional receptors compared with junctional ones. 6. It is concluded that the sustained depolarization of the endplate by SCh results largely from an action on the perijunctional receptor in mice and, unlike cats, the neuromuscular block by SCh is not due to the depolarization per se but rather to a direct attenuation of endplate potential." @default.
- W1967924344 created "2016-06-24" @default.
- W1967924344 creator A5002896915 @default.
- W1967924344 creator A5069433135 @default.
- W1967924344 creator A5085157192 @default.
- W1967924344 date "1989-12-01" @default.
- W1967924344 modified "2023-10-16" @default.
- W1967924344 title "Selective antagonism to succinylcholine-induced depolarization by α-bungarotoxin with respect to the mode of action of depolarizing agents" @default.
- W1967924344 cites W1974691120 @default.
- W1967924344 cites W1992119853 @default.
- W1967924344 cites W1995117830 @default.
- W1967924344 cites W2012779430 @default.
- W1967924344 cites W2013680069 @default.
- W1967924344 cites W20266633 @default.
- W1967924344 cites W2027985487 @default.
- W1967924344 cites W2040272192 @default.
- W1967924344 cites W2054491405 @default.
- W1967924344 cites W2076939358 @default.
- W1967924344 cites W2083423657 @default.
- W1967924344 cites W2125507565 @default.
- W1967924344 cites W2134148303 @default.
- W1967924344 cites W2134650948 @default.
- W1967924344 cites W2339498751 @default.
- W1967924344 cites W2398203096 @default.
- W1967924344 cites W34476297 @default.
- W1967924344 cites W52128264 @default.
- W1967924344 cites W68154933 @default.
- W1967924344 doi "https://doi.org/10.1111/j.1476-5381.1989.tb12691.x" @default.
- W1967924344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1854799" @default.
- W1967924344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2611499" @default.
- W1967924344 hasPublicationYear "1989" @default.
- W1967924344 type Work @default.
- W1967924344 sameAs 1967924344 @default.
- W1967924344 citedByCount "8" @default.
- W1967924344 countsByYear W19679243442017 @default.
- W1967924344 countsByYear W19679243442019 @default.
- W1967924344 crossrefType "journal-article" @default.
- W1967924344 hasAuthorship W1967924344A5002896915 @default.
- W1967924344 hasAuthorship W1967924344A5069433135 @default.
- W1967924344 hasAuthorship W1967924344A5085157192 @default.
- W1967924344 hasBestOaLocation W19679243442 @default.
- W1967924344 hasConcept C12554922 @default.
- W1967924344 hasConcept C126322002 @default.
- W1967924344 hasConcept C134018914 @default.
- W1967924344 hasConcept C169760540 @default.
- W1967924344 hasConcept C170493617 @default.
- W1967924344 hasConcept C185592680 @default.
- W1967924344 hasConcept C2775910092 @default.
- W1967924344 hasConcept C2777186327 @default.
- W1967924344 hasConcept C2777240379 @default.
- W1967924344 hasConcept C2777383412 @default.
- W1967924344 hasConcept C2909770972 @default.
- W1967924344 hasConcept C3020341438 @default.
- W1967924344 hasConcept C4141045 @default.
- W1967924344 hasConcept C55493867 @default.
- W1967924344 hasConcept C71924100 @default.
- W1967924344 hasConcept C80161118 @default.
- W1967924344 hasConcept C86803240 @default.
- W1967924344 hasConceptScore W1967924344C12554922 @default.
- W1967924344 hasConceptScore W1967924344C126322002 @default.
- W1967924344 hasConceptScore W1967924344C134018914 @default.
- W1967924344 hasConceptScore W1967924344C169760540 @default.
- W1967924344 hasConceptScore W1967924344C170493617 @default.
- W1967924344 hasConceptScore W1967924344C185592680 @default.
- W1967924344 hasConceptScore W1967924344C2775910092 @default.
- W1967924344 hasConceptScore W1967924344C2777186327 @default.
- W1967924344 hasConceptScore W1967924344C2777240379 @default.
- W1967924344 hasConceptScore W1967924344C2777383412 @default.
- W1967924344 hasConceptScore W1967924344C2909770972 @default.
- W1967924344 hasConceptScore W1967924344C3020341438 @default.
- W1967924344 hasConceptScore W1967924344C4141045 @default.
- W1967924344 hasConceptScore W1967924344C55493867 @default.
- W1967924344 hasConceptScore W1967924344C71924100 @default.
- W1967924344 hasConceptScore W1967924344C80161118 @default.
- W1967924344 hasConceptScore W1967924344C86803240 @default.
- W1967924344 hasLocation W19679243441 @default.
- W1967924344 hasLocation W19679243442 @default.
- W1967924344 hasLocation W19679243443 @default.
- W1967924344 hasLocation W19679243444 @default.
- W1967924344 hasOpenAccess W1967924344 @default.
- W1967924344 hasPrimaryLocation W19679243441 @default.
- W1967924344 hasRelatedWork W1966562800 @default.
- W1967924344 hasRelatedWork W1967924344 @default.
- W1967924344 hasRelatedWork W1973739933 @default.
- W1967924344 hasRelatedWork W1981251616 @default.
- W1967924344 hasRelatedWork W1988684681 @default.
- W1967924344 hasRelatedWork W2029008674 @default.
- W1967924344 hasRelatedWork W2065332506 @default.
- W1967924344 hasRelatedWork W2086862216 @default.
- W1967924344 hasRelatedWork W2395287283 @default.
- W1967924344 hasRelatedWork W2081122943 @default.
- W1967924344 isParatext "false" @default.
- W1967924344 isRetracted "false" @default.
- W1967924344 magId "1967924344" @default.
- W1967924344 workType "article" @default.