FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967939295> ?p ?o ?g. }

• W1967939295 endingPage "333" @default.
• W1967939295 startingPage "328" @default.
• W1967939295 abstract "Cell invasion through basement membrane (BM) occurs in many physiological and pathological contexts. MIG-10, the Caenorhabditis elegans Lamellipodin (Lpd), regulates diverse biological processes. Its function and regulation in cell invasive behavior remain unclear. Using anchor cell (AC) invasion in C. elegans as an in vivo invasion model, we have previously found that mig-10's activity is largely outside of UNC-6 (netrin) signaling, a chemical cue directing AC invasion. We have shown that MIG-10 is a target of the transcription factor FOS-1A and facilitates BM breaching. Combining genetics and imaging analyses, we report that MIG-10 synergizes with UNC-6 to promote AC attachment to the BM, revealing a functional role for MIG-10 in stabilizing AC-BM adhesion. MIG-10 is also required for F-actin accumulation in the absence of UNC-6. Further, we identify mig-10 as a transcriptional target negatively regulated by EGL-43A (C. elegans Evi-1 proto-oncogene), a transcription factor positively controlled by FOS-1A. The revelation of this negative regulation unmasks an incoherent feedforward circuit existing among fos-1, egl-43 and mig-10. Moreover, our study suggests the functional importance of the negative regulation on mig-10 expression by showing that excessive MIG-10 impairs AC invasion. Thus, we provide new insight into MIG-10's function and its complex transcriptional regulation during cell invasive behavior." @default.
• W1967939295 created "2016-06-24" @default.
• W1967939295 creator A5001358544 @default.
• W1967939295 creator A5010359215 @default.
• W1967939295 creator A5014466674 @default.
• W1967939295 creator A5018177794 @default.
• W1967939295 creator A5052267876 @default.
• W1967939295 creator A5053275663 @default.
• W1967939295 date "2014-09-01" @default.
• W1967939295 modified "2023-09-26" @default.
• W1967939295 title "MIG-10 (Lamellipodin) stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans" @default.
• W1967939295 cites W1581412826 @default.
• W1967939295 cites W1921244251 @default.
• W1967939295 cites W1944127002 @default.
• W1967939295 cites W1963709177 @default.
• W1967939295 cites W1983464008 @default.
• W1967939295 cites W1999644120 @default.
• W1967939295 cites W2003241987 @default.
• W1967939295 cites W2012470118 @default.
• W1967939295 cites W2018702739 @default.
• W1967939295 cites W2055299217 @default.
• W1967939295 cites W2059473757 @default.
• W1967939295 cites W2059934514 @default.
• W1967939295 cites W2061425021 @default.
• W1967939295 cites W2063220206 @default.
• W1967939295 cites W2086641174 @default.
• W1967939295 cites W2087153409 @default.
• W1967939295 cites W2093921289 @default.
• W1967939295 cites W2094063800 @default.
• W1967939295 cites W2112056725 @default.
• W1967939295 cites W2134891268 @default.
• W1967939295 cites W2139443838 @default.
• W1967939295 cites W2148454908 @default.
• W1967939295 cites W2157809114 @default.
• W1967939295 cites W2158146506 @default.
• W1967939295 cites W2164494941 @default.
• W1967939295 cites W2168539398 @default.
• W1967939295 doi "https://doi.org/10.1016/j.bbrc.2014.08.049" @default.
• W1967939295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4438536" @default.
• W1967939295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25148942" @default.
• W1967939295 hasPublicationYear "2014" @default.
• W1967939295 type Work @default.
• W1967939295 sameAs 1967939295 @default.
• W1967939295 citedByCount "12" @default.
• W1967939295 countsByYear W19679392952017 @default.
• W1967939295 countsByYear W19679392952018 @default.
• W1967939295 countsByYear W19679392952019 @default.
• W1967939295 countsByYear W19679392952020 @default.
• W1967939295 countsByYear W19679392952021 @default.
• W1967939295 countsByYear W19679392952022 @default.
• W1967939295 countsByYear W19679392952023 @default.
• W1967939295 crossrefType "journal-article" @default.
• W1967939295 hasAuthorship W1967939295A5001358544 @default.
• W1967939295 hasAuthorship W1967939295A5010359215 @default.
• W1967939295 hasAuthorship W1967939295A5014466674 @default.
• W1967939295 hasAuthorship W1967939295A5018177794 @default.
• W1967939295 hasAuthorship W1967939295A5052267876 @default.
• W1967939295 hasAuthorship W1967939295A5053275663 @default.
• W1967939295 hasBestOaLocation W19679392952 @default.
• W1967939295 hasConcept C104317684 @default.
• W1967939295 hasConcept C138885662 @default.
• W1967939295 hasConcept C1491633281 @default.
• W1967939295 hasConcept C179926584 @default.
• W1967939295 hasConcept C27153228 @default.
• W1967939295 hasConcept C2778944004 @default.
• W1967939295 hasConcept C41895202 @default.
• W1967939295 hasConcept C54355233 @default.
• W1967939295 hasConcept C85789140 @default.
• W1967939295 hasConcept C86339819 @default.
• W1967939295 hasConcept C86803240 @default.
• W1967939295 hasConcept C95444343 @default.
• W1967939295 hasConceptScore W1967939295C104317684 @default.
• W1967939295 hasConceptScore W1967939295C138885662 @default.
• W1967939295 hasConceptScore W1967939295C1491633281 @default.
• W1967939295 hasConceptScore W1967939295C179926584 @default.
• W1967939295 hasConceptScore W1967939295C27153228 @default.
• W1967939295 hasConceptScore W1967939295C2778944004 @default.
• W1967939295 hasConceptScore W1967939295C41895202 @default.
• W1967939295 hasConceptScore W1967939295C54355233 @default.
• W1967939295 hasConceptScore W1967939295C85789140 @default.
• W1967939295 hasConceptScore W1967939295C86339819 @default.
• W1967939295 hasConceptScore W1967939295C86803240 @default.
• W1967939295 hasConceptScore W1967939295C95444343 @default.
• W1967939295 hasFunder F4320321001 @default.
• W1967939295 hasFunder F4320321106 @default.
• W1967939295 hasFunder F4320321540 @default.
• W1967939295 hasIssue "3" @default.
• W1967939295 hasLocation W19679392951 @default.
• W1967939295 hasLocation W19679392952 @default.
• W1967939295 hasLocation W19679392953 @default.
• W1967939295 hasLocation W19679392954 @default.
• W1967939295 hasOpenAccess W1967939295 @default.
• W1967939295 hasPrimaryLocation W19679392951 @default.
• W1967939295 hasRelatedWork W1494166566 @default.
• W1967939295 hasRelatedWork W152093826 @default.
• W1967939295 hasRelatedWork W1790932677 @default.
• W1967939295 hasRelatedWork W2004997414 @default.
• W1967939295 hasRelatedWork W2018050005 @default.

• next