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- W1967942011 abstract "In view of the deficits of sphingolipids and of nervonic acid in presence of normal quantities of cholesterol and total proteins in MS white matter reported earlier, the fatty acids of these lipids and of their possible precursors were analyzed. Small quantities of ceramides were present in all specimens. These, as well as the cerebrosides of 2 MS gray matters showed decreased ratios of long chain monounsaturated fatty acids. Reduction of the ratio of nervonic acid was succinct in the sphingomyelins and ceramides of several MS white matters and of the plaques, and was noted, to a lesser degree, in their cerebrosides and sulfatides. This was associated with an increase of the stearic acid ratio. Free fatty acids of both gray and white matter contained large proportions of C 16:0, 18:0, 18:1 and 20:4, and only minimal ones of C 24:0 acids. These findings in addition to absence of C 26:1 acid in ceramides suggest that elongation and desaturation are taking place during in vivo biosynthesis of cerebrosides and sphingomyelins. These processes appear to be deficient in MS and are discussed in context with biochemical and immunologic findings by other authors. Psychosine was not found in any of the adult or in one infants brain and its role as an in vivo precursor for sphingolipids is questionable." @default.
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- W1967942011 date "1972-01-01" @default.
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- W1967942011 title "Sphingolipids and their precursors in human brain (Normal and MS)" @default.
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- W1967942011 doi "https://doi.org/10.1007/bf00316160" @default.
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