FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967946769> ?p ?o ?g. }

• W1967946769 endingPage "414" @default.
• W1967946769 startingPage "407" @default.
• W1967946769 abstract "A pulse of thimerosal (TMS), a sulfhydryl reagent, induces an instantaneous, complete and long-lasting microtubule interphasic network disassembly in mouse primary oocytes, correlated with the irreversible inhibition of meiosis reinitiation This inhibition is bypassed by dithiothreitol (DTT) while thiosalicylic acid, an analog of TMS, does induce neither microtubules depolymerisation nor inhibition of reinitiation and resumption of meiosis. This strongly suggests that the dramatic and pleiotropic inhibitory effect of TMS is specifically related to its sulfhydryl group oxidising activity of critical molecules among which tubulin. In contrast to DTT, okadaic acid (OA), known to bypass the inhibitory effect of drugs interfering with protein kinase activities, induces a late chromatin condensation and GVBD in TMS-pulsed oocytes as compared to the control situation, with no significant concomitant microtubule assembly. These cytological features are suggested to be indirectly induced by a late MAPK activation and confirm that a very early thiol oxidation induced by TMS exerts a much more dramatic effect on resumption of meiosis than any pharmacological manipulation of protein kinase activities leading to activation of MPF. Finally, taxol was shown to promote tubulin polymerisation even when microtubules were irreversibly disassembled by thiol oxidation but fails to restore the ability to undergo maturation." @default.
• W1967946769 created "2016-06-24" @default.
• W1967946769 creator A5002935968 @default.
• W1967946769 creator A5029712506 @default.
• W1967946769 creator A5044267728 @default.
• W1967946769 creator A5057076667 @default.
• W1967946769 date "2003-09-01" @default.
• W1967946769 modified "2023-09-27" @default.
• W1967946769 title "Effect of taxol and okadaic acid on microtubule dynamics in thimerosal-arrested primary mouse oocytes: a confocal study" @default.
• W1967946769 cites W130478101 @default.
• W1967946769 cites W1518265004 @default.
• W1967946769 cites W1532237107 @default.
• W1967946769 cites W1567797793 @default.
• W1967946769 cites W1574529051 @default.
• W1967946769 cites W1900946340 @default.
• W1967946769 cites W191075509 @default.
• W1967946769 cites W1927345484 @default.
• W1967946769 cites W1968778118 @default.
• W1967946769 cites W1974012414 @default.
• W1967946769 cites W1978945144 @default.
• W1967946769 cites W1981617042 @default.
• W1967946769 cites W1986260241 @default.
• W1967946769 cites W1986571317 @default.
• W1967946769 cites W2000378381 @default.
• W1967946769 cites W2001644793 @default.
• W1967946769 cites W2003914219 @default.
• W1967946769 cites W2010134182 @default.
• W1967946769 cites W2013864534 @default.
• W1967946769 cites W2015335079 @default.
• W1967946769 cites W2018122591 @default.
• W1967946769 cites W2020310614 @default.
• W1967946769 cites W2020482885 @default.
• W1967946769 cites W2022817962 @default.
• W1967946769 cites W2050998289 @default.
• W1967946769 cites W2056354464 @default.
• W1967946769 cites W2060903107 @default.
• W1967946769 cites W2062143530 @default.
• W1967946769 cites W2067299834 @default.
• W1967946769 cites W2072766088 @default.
• W1967946769 cites W2074685593 @default.
• W1967946769 cites W2086526874 @default.
• W1967946769 cites W2093188668 @default.
• W1967946769 cites W2109204235 @default.
• W1967946769 cites W2120863005 @default.
• W1967946769 cites W2126345885 @default.
• W1967946769 cites W2217663772 @default.
• W1967946769 cites W2290777709 @default.
• W1967946769 cites W2343043741 @default.
• W1967946769 cites W2389429156 @default.
• W1967946769 cites W2395503902 @default.
• W1967946769 cites W2469776836 @default.
• W1967946769 cites W2471483829 @default.
• W1967946769 cites W2750045786 @default.
• W1967946769 cites W952146727 @default.
• W1967946769 doi "https://doi.org/10.1016/s0248-4900(03)00088-1" @default.
• W1967946769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14519558" @default.
• W1967946769 hasPublicationYear "2003" @default.
• W1967946769 type Work @default.
• W1967946769 sameAs 1967946769 @default.
• W1967946769 citedByCount "4" @default.
• W1967946769 crossrefType "journal-article" @default.
• W1967946769 hasAuthorship W1967946769A5002935968 @default.
• W1967946769 hasAuthorship W1967946769A5029712506 @default.
• W1967946769 hasAuthorship W1967946769A5044267728 @default.
• W1967946769 hasAuthorship W1967946769A5057076667 @default.
• W1967946769 hasConcept C104317684 @default.
• W1967946769 hasConcept C11960822 @default.
• W1967946769 hasConcept C120504264 @default.
• W1967946769 hasConcept C12554922 @default.
• W1967946769 hasConcept C148196450 @default.
• W1967946769 hasConcept C1491633281 @default.
• W1967946769 hasConcept C178666793 @default.
• W1967946769 hasConcept C181199279 @default.
• W1967946769 hasConcept C184235292 @default.
• W1967946769 hasConcept C20418707 @default.
• W1967946769 hasConcept C2776953658 @default.
• W1967946769 hasConcept C2777824588 @default.
• W1967946769 hasConcept C29537977 @default.
• W1967946769 hasConcept C45413362 @default.
• W1967946769 hasConcept C55493867 @default.
• W1967946769 hasConcept C6902291 @default.
• W1967946769 hasConcept C84425145 @default.
• W1967946769 hasConcept C86803240 @default.
• W1967946769 hasConcept C95444343 @default.
• W1967946769 hasConceptScore W1967946769C104317684 @default.
• W1967946769 hasConceptScore W1967946769C11960822 @default.
• W1967946769 hasConceptScore W1967946769C120504264 @default.
• W1967946769 hasConceptScore W1967946769C12554922 @default.
• W1967946769 hasConceptScore W1967946769C148196450 @default.
• W1967946769 hasConceptScore W1967946769C1491633281 @default.
• W1967946769 hasConceptScore W1967946769C178666793 @default.
• W1967946769 hasConceptScore W1967946769C181199279 @default.
• W1967946769 hasConceptScore W1967946769C184235292 @default.
• W1967946769 hasConceptScore W1967946769C20418707 @default.
• W1967946769 hasConceptScore W1967946769C2776953658 @default.
• W1967946769 hasConceptScore W1967946769C2777824588 @default.
• W1967946769 hasConceptScore W1967946769C29537977 @default.
• W1967946769 hasConceptScore W1967946769C45413362 @default.

• next