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- W1967948152 abstract "The metabolome refers to the entire set of small molecules, or metabolites, within a biological sample. These molecules are involved in many fundamental intracellular functions and reflect the cell's physiological condition. The ability to detect and identify metabolites and determine and monitor their amounts at the single cell level enables an exciting range of studies of biological variation and functional heterogeneity between cells, even within a presumably homogenous cell population. Significant progress has been made in the development and application of bioanalytical tools for single cell metabolomics based on mass spectrometry, microfluidics, and capillary separations. Remarkable improvements in the sensitivity, specificity, and throughput of these approaches enable investigation of multiple metabolites simultaneously in a range of individual cell samples." @default.
- W1967948152 created "2016-06-24" @default.
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- W1967948152 date "2013-02-01" @default.
- W1967948152 modified "2023-10-10" @default.
- W1967948152 title "Progress toward single cell metabolomics" @default.
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- W1967948152 doi "https://doi.org/10.1016/j.copbio.2012.10.021" @default.
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