FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967949725> ?p ?o ?g. }

• W1967949725 endingPage "825" @default.
• W1967949725 startingPage "815" @default.
• W1967949725 abstract "In the ocular lens, gap junctional communication is a key component of homeostatic mechanisms preventing cataract formation. Gap junctions in rodent lens fibers contain two known intercellular channel-forming proteins, connexin50 (Cx50) and Cx46. Since targeted ablation of Cx46 has been shown to cause senile-type nuclear opacities, it appears that Cx50 alone cannot meet homeostatic requirements. To determine if lens pathology arises from a reduction in levels of communication or the loss of a connexin-specific function, we have generated mice with a targeted deletion of the Cx50 gene. Cx50-null mice exhibited microphthalmia and nuclear cataracts. At postnatal day 14 (P14), Cx50-knockout eyes weighed 32% less than controls, whereas lens mass was reduced by 46%. Cx50-knockout lenses also developed zonular pulverulent cataracts, and lens abnormalities were detected by P7. Deletion of Cx50 did not alter the amounts or distributions of Cx46 or Cx43, a component of lens epithelial junctions. In addition, intercellular passage of tracers revealed the persistence of communication between all cell types in the Cx50-knockout lens. These results demonstrate that Cx50 is required not only for maintenance of lens transparency but also for normal eye growth. Furthermore, these data indicate that unique functional properties of both Cx46 and Cx50 are required for proper lens development." @default.
• W1967949725 created "2016-06-24" @default.
• W1967949725 creator A5016887560 @default.
• W1967949725 creator A5044719208 @default.
• W1967949725 creator A5070309801 @default.
• W1967949725 date "1998-11-02" @default.
• W1967949725 modified "2023-10-10" @default.
• W1967949725 title "Targeted Ablation of Connexin50 in Mice Results in Microphthalmia and Zonular Pulverulent Cataracts" @default.
• W1967949725 cites W1481400293 @default.
• W1967949725 cites W1482809510 @default.
• W1967949725 cites W1968411842 @default.
• W1967949725 cites W1977845454 @default.
• W1967949725 cites W1987580294 @default.
• W1967949725 cites W1987681547 @default.
• W1967949725 cites W1988783785 @default.
• W1967949725 cites W2004617457 @default.
• W1967949725 cites W2010167207 @default.
• W1967949725 cites W2017688904 @default.
• W1967949725 cites W2044853699 @default.
• W1967949725 cites W2046241907 @default.
• W1967949725 cites W2049176532 @default.
• W1967949725 cites W2050794383 @default.
• W1967949725 cites W2056686891 @default.
• W1967949725 cites W2061527200 @default.
• W1967949725 cites W2064855528 @default.
• W1967949725 cites W2066564051 @default.
• W1967949725 cites W2069035576 @default.
• W1967949725 cites W2098660246 @default.
• W1967949725 cites W2108317548 @default.
• W1967949725 cites W2109127883 @default.
• W1967949725 cites W2123828628 @default.
• W1967949725 cites W2161003888 @default.
• W1967949725 cites W2167103784 @default.
• W1967949725 cites W2168734089 @default.
• W1967949725 cites W2327402949 @default.
• W1967949725 cites W2399204169 @default.
• W1967949725 cites W2409058874 @default.
• W1967949725 cites W2411813740 @default.
• W1967949725 cites W58006669 @default.
• W1967949725 doi "https://doi.org/10.1083/jcb.143.3.815" @default.
• W1967949725 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2148149" @default.
• W1967949725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9813099" @default.
• W1967949725 hasPublicationYear "1998" @default.
• W1967949725 type Work @default.
• W1967949725 sameAs 1967949725 @default.
• W1967949725 citedByCount "338" @default.
• W1967949725 countsByYear W19679497252012 @default.
• W1967949725 countsByYear W19679497252013 @default.
• W1967949725 countsByYear W19679497252014 @default.
• W1967949725 countsByYear W19679497252015 @default.
• W1967949725 countsByYear W19679497252016 @default.
• W1967949725 countsByYear W19679497252017 @default.
• W1967949725 countsByYear W19679497252018 @default.
• W1967949725 countsByYear W19679497252019 @default.
• W1967949725 countsByYear W19679497252020 @default.
• W1967949725 countsByYear W19679497252021 @default.
• W1967949725 countsByYear W19679497252022 @default.
• W1967949725 countsByYear W19679497252023 @default.
• W1967949725 crossrefType "journal-article" @default.
• W1967949725 hasAuthorship W1967949725A5016887560 @default.
• W1967949725 hasAuthorship W1967949725A5044719208 @default.
• W1967949725 hasAuthorship W1967949725A5070309801 @default.
• W1967949725 hasBestOaLocation W19679497251 @default.
• W1967949725 hasConcept C104317684 @default.
• W1967949725 hasConcept C151730666 @default.
• W1967949725 hasConcept C15336307 @default.
• W1967949725 hasConcept C158157758 @default.
• W1967949725 hasConcept C182704531 @default.
• W1967949725 hasConcept C2780225610 @default.
• W1967949725 hasConcept C2780228694 @default.
• W1967949725 hasConcept C2909221355 @default.
• W1967949725 hasConcept C54355233 @default.
• W1967949725 hasConcept C79879829 @default.
• W1967949725 hasConcept C86803240 @default.
• W1967949725 hasConcept C95444343 @default.
• W1967949725 hasConceptScore W1967949725C104317684 @default.
• W1967949725 hasConceptScore W1967949725C151730666 @default.
• W1967949725 hasConceptScore W1967949725C15336307 @default.
• W1967949725 hasConceptScore W1967949725C158157758 @default.
• W1967949725 hasConceptScore W1967949725C182704531 @default.
• W1967949725 hasConceptScore W1967949725C2780225610 @default.
• W1967949725 hasConceptScore W1967949725C2780228694 @default.
• W1967949725 hasConceptScore W1967949725C2909221355 @default.
• W1967949725 hasConceptScore W1967949725C54355233 @default.
• W1967949725 hasConceptScore W1967949725C79879829 @default.
• W1967949725 hasConceptScore W1967949725C86803240 @default.
• W1967949725 hasConceptScore W1967949725C95444343 @default.
• W1967949725 hasIssue "3" @default.
• W1967949725 hasLocation W19679497251 @default.
• W1967949725 hasLocation W19679497252 @default.
• W1967949725 hasLocation W19679497253 @default.
• W1967949725 hasLocation W19679497254 @default.
• W1967949725 hasOpenAccess W1967949725 @default.
• W1967949725 hasPrimaryLocation W19679497251 @default.
• W1967949725 hasRelatedWork W1744239203 @default.
• W1967949725 hasRelatedWork W1989127634 @default.
• W1967949725 hasRelatedWork W1996470658 @default.
• W1967949725 hasRelatedWork W2040850663 @default.

• next