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• W1967968986 startingPage "1736" @default.
• W1967968986 abstract "Respiratory distress syndrome (RDS), which is the leading cause of death in premature infants, is caused by surfactant deficiency. The most critical and abundant phospholipid in pulmonary surfactant is saturated phosphatidylcholine (SatPC), which is synthesized in alveolar type II cells de novo or by the deacylation-reacylation of existing phosphatidylcholine species. We recently cloned and partially characterized a mouse enzyme with characteristics of a lung lysophosphatidylcholine acyltransferase (LPCAT1) that we predicted would be involved in surfactant synthesis. Here, we describe our studies investigating whether LPCAT1 is required for pulmonary surfactant homeostasis. To address this issue, we generated mice bearing a hypomorphic allele of Lpcat1 (referred to herein as Lpcat1GT/GT mice) using a genetrap strategy. Newborn Lpcat1GT/GT mice showed varying perinatal mortality from respiratory failure, with affected animals demonstrating hallmarks of respiratory distress such as atelectasis and hyaline membranes. Lpcat1 mRNA levels were reduced in newborn Lpcat1GT/GT mice and directly correlated with SatPC content, LPCAT1 activity, and survival. Surfactant isolated from dead Lpcat1GT/GT mice failed to reduce minimum surface tension to wild-type levels. Collectively, these data demonstrate that full LPCAT1 activity is required to achieve the levels of SatPC essential for the transition to air breathing." @default.
• W1967968986 created "2016-06-24" @default.
• W1967968986 creator A5007486174 @default.
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• W1967968986 creator A5058059519 @default.
• W1967968986 creator A5076459383 @default.
• W1967968986 date "2010-05-03" @default.
• W1967968986 modified "2023-10-18" @default.
• W1967968986 title "LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice" @default.
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• W1967968986 doi "https://doi.org/10.1172/jci38061" @default.
• W1967968986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2877925" @default.
• W1967968986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20407208" @default.
• W1967968986 hasPublicationYear "2010" @default.
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