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• W1967971330 abstract "<i>Background:</i> Resistant Gram-positive bacteria are causing increasing concern in clinical practice. This work investigated theefficacy of AP-CECT7121 (an antimicrobial peptide isolated from an environmental strain of <i>Enterococcus faecalis </i>CECT7121) against various pathogenic Gram-positive bacteria. <i>Methods:</i> Strains were isolated from intensive care unit patients unresponsive to standard antibiotic treatments. Inhibitory activity of AP-CECT7121 was assessed using the agar-well diffusion method. The most resistant isolates from each species screened <i>(Enterococcus faecium</i>, <i>Enterococcus faecalis,</i><i>Staphylococcus aureus</i>, <i>Streptococcus pneumoniae</i>, <i>Streptococcus pyogenes</i>, <i>Clostridium perfringens</i> and <i>Clostridium difficile)</i> were further examined in time-killing curve studies. <i>Results:</i> These bactericidal kinetic experiments demonstrated a rapid killing effect with no viable bacteria being detected within 30 and 90 min for enterococcal and streptococcal strains and 180 min for community-acquired methicillin-resistant <i>S. aureus</i> and <i>C. perfringens</i>: viable counts for <i>C. difficile</i> were threefold decreased after 90 min. <i>Conclusions:</i> AP-CECT7121 may provide a novel strategy for treating potentially fatal clinical infections in hospitalized patients." @default.
• W1967971330 created "2016-06-24" @default.
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• W1967971330 date "2009-01-01" @default.
• W1967971330 modified "2023-09-25" @default.
• W1967971330 title "Assessment of the in vitro Efficacy of the Novel Antimicrobial Peptide CECT7121 against Human Gram-Positive Bacteria from Serious Infections Refractory to Treatment" @default.
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• W1967971330 doi "https://doi.org/10.1159/000223069" @default.
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