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- W1967974311 abstract "The binding of [3H]cyclic AMP to cell surface receptors of differentiated D. discoideum cells at 25° is an oscillatory process with a periodicity of 2 min. This alternating change in the cells' binding capacity for cyclic AMP may be the basis for the refractory period to cyclic AMP stimulation, an essential feature of the chemotactic system. The incorporation of [32P] by whole cells from [γ32P]ATP is also oscillatory with a periodicity identical to that of [3H]cyclic AMP binding. However, the two processes are inversely related in time such that periods of maximal cyclic AMP binding correspond to periods of minimal cellular phosphorylation. These results suggest a receptor kinase/phosphatase mediated desensitization of the cyclic AMP receptor." @default.
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- W1967974311 date "1977-10-01" @default.
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- W1967974311 title "Reciprocal periodicity in cyclic AMP binding and phosphorylation of differentiating Dictyostelium discoideum cells" @default.
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- W1967974311 doi "https://doi.org/10.1016/0006-291x(77)90533-2" @default.
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