FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967977237> ?p ?o ?g. }

• W1967977237 endingPage "AB120" @default.
• W1967977237 startingPage "AB120" @default.
• W1967977237 abstract "RationaleSystemic mastocytosis (SM) patients with later onset of disease have a poorer prognosis than younger patients with this disorder.MethodsPatients 70 years of age and older at the time of the diagnosis of SM were sorted from the Mayo Clinic Database (1990 to the present). We examined associated hematologic disorders, genetic abnormalities, bone marrow cellularity, tryptase levels and other findings.Results43 patients (17 women, 26 men, average age 76.2 years) qualified for further evaluation. 10 patients (23%) had no associated hematologic disorder. Single or multiple chromosomal abnormalities, exclusive of the KIT Asp816Val mutation, were detected in 7 of 43 patients (16%); however there was no predominant alteration. Slight to marked bone marrow hypercellularity was found in 29 patients (67%) while hypocellularity was found in 2 patients. Hematologic disorders, many with an associated additional second hematologic abnormality included CMML5, AML 1, myelodysplastic syndrome 8, eosinophilia 8, myelofibrosis1, myeloproliferative disorder 1, multiple myeloma 1, B cell lymphoma 1, and thrombocytopenia 3. Some blood disorders predated the finding of mastocytosis: thrombasthenia (2 yr), anemia (6 mo), pancytopenia (4 yr), MDS (9 yrs), MDS with RARS (2 yrs), B-cell lymphoma (5 yrs), thrombocytopenia (> 20 yrs). Tryptase levels were available for 41 patients and were elevated in 40 with the highest average value found among those with associated thrombocytopenia.ConclusionsPatients whose diagnosis of SM is established at or above age 70 have a high frequency of secondary hematologic disorders, bone marrow hypercellularity and chromosomal abnormalities. RationaleSystemic mastocytosis (SM) patients with later onset of disease have a poorer prognosis than younger patients with this disorder. Systemic mastocytosis (SM) patients with later onset of disease have a poorer prognosis than younger patients with this disorder. MethodsPatients 70 years of age and older at the time of the diagnosis of SM were sorted from the Mayo Clinic Database (1990 to the present). We examined associated hematologic disorders, genetic abnormalities, bone marrow cellularity, tryptase levels and other findings. Patients 70 years of age and older at the time of the diagnosis of SM were sorted from the Mayo Clinic Database (1990 to the present). We examined associated hematologic disorders, genetic abnormalities, bone marrow cellularity, tryptase levels and other findings. Results43 patients (17 women, 26 men, average age 76.2 years) qualified for further evaluation. 10 patients (23%) had no associated hematologic disorder. Single or multiple chromosomal abnormalities, exclusive of the KIT Asp816Val mutation, were detected in 7 of 43 patients (16%); however there was no predominant alteration. Slight to marked bone marrow hypercellularity was found in 29 patients (67%) while hypocellularity was found in 2 patients. Hematologic disorders, many with an associated additional second hematologic abnormality included CMML5, AML 1, myelodysplastic syndrome 8, eosinophilia 8, myelofibrosis1, myeloproliferative disorder 1, multiple myeloma 1, B cell lymphoma 1, and thrombocytopenia 3. Some blood disorders predated the finding of mastocytosis: thrombasthenia (2 yr), anemia (6 mo), pancytopenia (4 yr), MDS (9 yrs), MDS with RARS (2 yrs), B-cell lymphoma (5 yrs), thrombocytopenia (> 20 yrs). Tryptase levels were available for 41 patients and were elevated in 40 with the highest average value found among those with associated thrombocytopenia. 43 patients (17 women, 26 men, average age 76.2 years) qualified for further evaluation. 10 patients (23%) had no associated hematologic disorder. Single or multiple chromosomal abnormalities, exclusive of the KIT Asp816Val mutation, were detected in 7 of 43 patients (16%); however there was no predominant alteration. Slight to marked bone marrow hypercellularity was found in 29 patients (67%) while hypocellularity was found in 2 patients. Hematologic disorders, many with an associated additional second hematologic abnormality included CMML5, AML 1, myelodysplastic syndrome 8, eosinophilia 8, myelofibrosis1, myeloproliferative disorder 1, multiple myeloma 1, B cell lymphoma 1, and thrombocytopenia 3. Some blood disorders predated the finding of mastocytosis: thrombasthenia (2 yr), anemia (6 mo), pancytopenia (4 yr), MDS (9 yrs), MDS with RARS (2 yrs), B-cell lymphoma (5 yrs), thrombocytopenia (> 20 yrs). Tryptase levels were available for 41 patients and were elevated in 40 with the highest average value found among those with associated thrombocytopenia. ConclusionsPatients whose diagnosis of SM is established at or above age 70 have a high frequency of secondary hematologic disorders, bone marrow hypercellularity and chromosomal abnormalities. Patients whose diagnosis of SM is established at or above age 70 have a high frequency of secondary hematologic disorders, bone marrow hypercellularity and chromosomal abnormalities." @default.
• W1967977237 created "2016-06-24" @default.
• W1967977237 creator A5059340199 @default.
• W1967977237 creator A5087836105 @default.
• W1967977237 date "2013-02-01" @default.
• W1967977237 modified "2023-10-17" @default.
• W1967977237 title "Systemic Mastocytosis in the Elderly" @default.
• W1967977237 doi "https://doi.org/10.1016/j.jaci.2012.12.1101" @default.
• W1967977237 hasPublicationYear "2013" @default.
• W1967977237 type Work @default.
• W1967977237 sameAs 1967977237 @default.
• W1967977237 citedByCount "0" @default.
• W1967977237 crossrefType "journal-article" @default.
• W1967977237 hasAuthorship W1967977237A5059340199 @default.
• W1967977237 hasAuthorship W1967977237A5087836105 @default.
• W1967977237 hasBestOaLocation W19679772371 @default.
• W1967977237 hasConcept C109159458 @default.
• W1967977237 hasConcept C126322002 @default.
• W1967977237 hasConcept C142724271 @default.
• W1967977237 hasConcept C203014093 @default.
• W1967977237 hasConcept C2776364478 @default.
• W1967977237 hasConcept C2778248108 @default.
• W1967977237 hasConcept C2779134260 @default.
• W1967977237 hasConcept C2779338263 @default.
• W1967977237 hasConcept C2779382419 @default.
• W1967977237 hasConcept C2779726688 @default.
• W1967977237 hasConcept C2780007613 @default.
• W1967977237 hasConcept C2780525284 @default.
• W1967977237 hasConcept C2780571819 @default.
• W1967977237 hasConcept C2780581156 @default.
• W1967977237 hasConcept C2780817109 @default.
• W1967977237 hasConcept C2781406822 @default.
• W1967977237 hasConcept C28328180 @default.
• W1967977237 hasConcept C2909606595 @default.
• W1967977237 hasConcept C2910729011 @default.
• W1967977237 hasConcept C54355233 @default.
• W1967977237 hasConcept C71924100 @default.
• W1967977237 hasConcept C86803240 @default.
• W1967977237 hasConcept C90924648 @default.
• W1967977237 hasConceptScore W1967977237C109159458 @default.
• W1967977237 hasConceptScore W1967977237C126322002 @default.
• W1967977237 hasConceptScore W1967977237C142724271 @default.
• W1967977237 hasConceptScore W1967977237C203014093 @default.
• W1967977237 hasConceptScore W1967977237C2776364478 @default.
• W1967977237 hasConceptScore W1967977237C2778248108 @default.
• W1967977237 hasConceptScore W1967977237C2779134260 @default.
• W1967977237 hasConceptScore W1967977237C2779338263 @default.
• W1967977237 hasConceptScore W1967977237C2779382419 @default.
• W1967977237 hasConceptScore W1967977237C2779726688 @default.
• W1967977237 hasConceptScore W1967977237C2780007613 @default.
• W1967977237 hasConceptScore W1967977237C2780525284 @default.
• W1967977237 hasConceptScore W1967977237C2780571819 @default.
• W1967977237 hasConceptScore W1967977237C2780581156 @default.
• W1967977237 hasConceptScore W1967977237C2780817109 @default.
• W1967977237 hasConceptScore W1967977237C2781406822 @default.
• W1967977237 hasConceptScore W1967977237C28328180 @default.
• W1967977237 hasConceptScore W1967977237C2909606595 @default.
• W1967977237 hasConceptScore W1967977237C2910729011 @default.
• W1967977237 hasConceptScore W1967977237C54355233 @default.
• W1967977237 hasConceptScore W1967977237C71924100 @default.
• W1967977237 hasConceptScore W1967977237C86803240 @default.
• W1967977237 hasConceptScore W1967977237C90924648 @default.
• W1967977237 hasIssue "2" @default.
• W1967977237 hasLocation W19679772371 @default.
• W1967977237 hasOpenAccess W1967977237 @default.
• W1967977237 hasPrimaryLocation W19679772371 @default.
• W1967977237 hasRelatedWork W1945366434 @default.
• W1967977237 hasRelatedWork W1996798270 @default.
• W1967977237 hasRelatedWork W2046616500 @default.
• W1967977237 hasRelatedWork W2057339349 @default.
• W1967977237 hasRelatedWork W2059732064 @default.
• W1967977237 hasRelatedWork W2095849180 @default.
• W1967977237 hasRelatedWork W2134684383 @default.
• W1967977237 hasRelatedWork W2411385959 @default.
• W1967977237 hasRelatedWork W2500019632 @default.
• W1967977237 hasRelatedWork W2880625729 @default.
• W1967977237 hasVolume "131" @default.
• W1967977237 isParatext "false" @default.
• W1967977237 isRetracted "false" @default.
• W1967977237 magId "1967977237" @default.
• W1967977237 workType "article" @default.