Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967977725> ?p ?o ?g. }
- W1967977725 endingPage "328" @default.
- W1967977725 startingPage "318" @default.
- W1967977725 abstract "Brain-derived neurotrophic factor (BDNF) is thought to regulate neuronal plasticity in developing and matured neurons, although the molecular mechanisms are less well characterized. We monitored changes in the intracellular calcium (Ca2+) levels induced by BDNF using a fluorescence Ca2+ indicator (Fluo-3) by means of confocal laser microscopy in rat cultured hippocampal neurons. BDNF acutely potentiated spontaneous Ca2+ oscillations in dendrites and also in the soma of several neurons, although it increased intracellular Ca2+ in only selective proportion of resting neurons without Ca2+ oscillations. The potentiation was observed both in the frequency and the amplitude of Ca2+ oscillations, completely blocked by K-252a, and significantly reduced by 2-aminophosphonovaleric acid. These findings suggest that BDNF increases glutamate release and N-methyl-d-aspartate (NMDA) channel-gated Ca2+ influx via TrkB and regulates the frequency and the amplitude of Ca2+ oscillations. BDNF may have the potential to modulate spontaneous Ca2+ oscillations to regulate neuronal plasticity in developing hippocampal neurons." @default.
- W1967977725 created "2016-06-24" @default.
- W1967977725 creator A5005841735 @default.
- W1967977725 creator A5032497424 @default.
- W1967977725 creator A5040438371 @default.
- W1967977725 creator A5078166439 @default.
- W1967977725 creator A5087822481 @default.
- W1967977725 date "1997-12-01" @default.
- W1967977725 modified "2023-10-12" @default.
- W1967977725 title "BDNF potentiates spontaneous Ca2+ oscillations in cultured hippocampal neurons" @default.
- W1967977725 cites W1531884888 @default.
- W1967977725 cites W1590809303 @default.
- W1967977725 cites W1830398839 @default.
- W1967977725 cites W1850032865 @default.
- W1967977725 cites W1863049993 @default.
- W1967977725 cites W1891880696 @default.
- W1967977725 cites W1968177638 @default.
- W1967977725 cites W1971263143 @default.
- W1967977725 cites W1973918689 @default.
- W1967977725 cites W1974972283 @default.
- W1967977725 cites W1979305117 @default.
- W1967977725 cites W1984929819 @default.
- W1967977725 cites W1989053030 @default.
- W1967977725 cites W1989920284 @default.
- W1967977725 cites W1991564793 @default.
- W1967977725 cites W1995374378 @default.
- W1967977725 cites W2005901591 @default.
- W1967977725 cites W2008994988 @default.
- W1967977725 cites W2011965698 @default.
- W1967977725 cites W2016943722 @default.
- W1967977725 cites W2020333978 @default.
- W1967977725 cites W2025611163 @default.
- W1967977725 cites W2027377352 @default.
- W1967977725 cites W2029863311 @default.
- W1967977725 cites W2035955813 @default.
- W1967977725 cites W2036341167 @default.
- W1967977725 cites W2039720772 @default.
- W1967977725 cites W2046174150 @default.
- W1967977725 cites W2049511526 @default.
- W1967977725 cites W2051493425 @default.
- W1967977725 cites W2051600135 @default.
- W1967977725 cites W2054336759 @default.
- W1967977725 cites W2054473035 @default.
- W1967977725 cites W2058713053 @default.
- W1967977725 cites W2061603242 @default.
- W1967977725 cites W2063368353 @default.
- W1967977725 cites W2065021869 @default.
- W1967977725 cites W2067763822 @default.
- W1967977725 cites W2069527370 @default.
- W1967977725 cites W2070094949 @default.
- W1967977725 cites W2072474651 @default.
- W1967977725 cites W2074698464 @default.
- W1967977725 cites W2075677730 @default.
- W1967977725 cites W2076843536 @default.
- W1967977725 cites W2078316783 @default.
- W1967977725 cites W2081720076 @default.
- W1967977725 cites W2086835104 @default.
- W1967977725 cites W2087081892 @default.
- W1967977725 cites W2088650980 @default.
- W1967977725 cites W2092841616 @default.
- W1967977725 cites W2099452732 @default.
- W1967977725 cites W2125403403 @default.
- W1967977725 cites W2134678910 @default.
- W1967977725 cites W2136024488 @default.
- W1967977725 cites W2157423347 @default.
- W1967977725 cites W2164180561 @default.
- W1967977725 cites W2169618920 @default.
- W1967977725 cites W2404892025 @default.
- W1967977725 cites W2410446460 @default.
- W1967977725 cites W4210982910 @default.
- W1967977725 cites W4249424055 @default.
- W1967977725 cites W44643732 @default.
- W1967977725 doi "https://doi.org/10.1016/s0006-8993(97)01052-4" @default.
- W1967977725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9459549" @default.
- W1967977725 hasPublicationYear "1997" @default.
- W1967977725 type Work @default.
- W1967977725 sameAs 1967977725 @default.
- W1967977725 citedByCount "57" @default.
- W1967977725 countsByYear W19679777252013 @default.
- W1967977725 countsByYear W19679777252014 @default.
- W1967977725 countsByYear W19679777252019 @default.
- W1967977725 countsByYear W19679777252021 @default.
- W1967977725 countsByYear W19679777252023 @default.
- W1967977725 crossrefType "journal-article" @default.
- W1967977725 hasAuthorship W1967977725A5005841735 @default.
- W1967977725 hasAuthorship W1967977725A5032497424 @default.
- W1967977725 hasAuthorship W1967977725A5040438371 @default.
- W1967977725 hasAuthorship W1967977725A5078166439 @default.
- W1967977725 hasAuthorship W1967977725A5087822481 @default.
- W1967977725 hasBestOaLocation W19679777252 @default.
- W1967977725 hasConcept C12554922 @default.
- W1967977725 hasConcept C148762608 @default.
- W1967977725 hasConcept C160539049 @default.
- W1967977725 hasConcept C169760540 @default.
- W1967977725 hasConcept C170493617 @default.
- W1967977725 hasConcept C185592680 @default.
- W1967977725 hasConcept C25274449 @default.
- W1967977725 hasConcept C2778790584 @default.