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- W1967987682 abstract "Replicon behavior in radiosensitive Ataxia telangiectasia (A-T) fibroblasts and mouse lymphoma L5178Y (LS) cells was studied by DNA fiber autoradiography. LS cells, irradiated at 13 Gy, showed a similar reduction in rate of DNA chain growth and initiation of replicons as did resistant (LR) cells. A progressive increase in the intensity of [3H]TdR labeling of many replicons was observed after irradiation in the LS cells, but not in LR cells. This indicated a reduced or absent endogenous dTTP supply after irradiation in the LS cells, implicating a defect in nucleoside precursor production. Irradiated normal human and A-T cells did not show this effect. After 2 Gy, the frequency of initiation of replicons into synthesis was temporarily reduced in the normal human but not in the A-T cells. After 20 Gy, the rate of DNA chain growth was preferentially reduced in the normal human cells, but an increase was observed in the A-T cells. This increased rate could be explained in terms of a normal supply of complexes involved in chain elongation being distributed over a reduced number of initiated replicon clusters in the A-T cells." @default.
- W1967987682 created "2016-06-24" @default.
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- W1967987682 date "1983-05-01" @default.
- W1967987682 modified "2023-09-23" @default.
- W1967987682 title "Differences in Replicon Behavior between X-Irradiation-Sensitive L5178Y Mouse Lymphoma Cells and A-T Fibroblasts Using DNA Fiber Autoradiography" @default.
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- W1967987682 doi "https://doi.org/10.2307/3575975" @default.
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