Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967997639> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1967997639 abstract "Current in vitro tools for evaluating neuronal guidance cues suffer from several drawbacks, including difficult substrate preparation and hard-to-interpret results. Microcontact printing of an alkanethiol self-assembled monolayer (SAM) provides a robust method for producing high-resolution protein patterns by protein adsorption from solution. However, cell and protein resistant glycol terminated monolayers are typically employed in the background, which prevents the evaluation of potential neuronal guidance cues. We have developed zwitterionic background monolayers that are protein-resistant, but remain cell-permissive. Using surface plasmon resonance imaging (SPRi) and cell-culture studies, we have demonstrated that these zwitterionic monolayers provide well-defined, non-receptor mediate cellular attachment through interactions with cell-surface glycosylation. Exploiting these properties, we have created a monolayer based stripe assay, where the interactions between neurons (cell bodies and neurites) and extracellular matrix (ECM) proteins or guidance cues may be observed and quantified. This system goes beyond current technologies, such as direct protein patterning and microfluidics, and is even capable of evaluating neuronal response to ECM protein, such as laminin." @default.
- W1967997639 created "2016-06-24" @default.
- W1967997639 creator A5005079621 @default.
- W1967997639 creator A5010572941 @default.
- W1967997639 creator A5018540261 @default.
- W1967997639 creator A5043048419 @default.
- W1967997639 date "2014-01-01" @default.
- W1967997639 modified "2023-09-29" @default.
- W1967997639 title "Cell-Permissive Protein-Resistant Substrates for Interrogating Neuronal Guidance Cues" @default.
- W1967997639 doi "https://doi.org/10.1016/j.bpj.2013.11.1235" @default.
- W1967997639 hasPublicationYear "2014" @default.
- W1967997639 type Work @default.
- W1967997639 sameAs 1967997639 @default.
- W1967997639 citedByCount "0" @default.
- W1967997639 crossrefType "journal-article" @default.
- W1967997639 hasAuthorship W1967997639A5005079621 @default.
- W1967997639 hasAuthorship W1967997639A5010572941 @default.
- W1967997639 hasAuthorship W1967997639A5018540261 @default.
- W1967997639 hasAuthorship W1967997639A5043048419 @default.
- W1967997639 hasBestOaLocation W19679976391 @default.
- W1967997639 hasConcept C106847996 @default.
- W1967997639 hasConcept C113246987 @default.
- W1967997639 hasConcept C12554922 @default.
- W1967997639 hasConcept C1491633281 @default.
- W1967997639 hasConcept C155672457 @default.
- W1967997639 hasConcept C171250308 @default.
- W1967997639 hasConcept C185592680 @default.
- W1967997639 hasConcept C189165786 @default.
- W1967997639 hasConcept C192562407 @default.
- W1967997639 hasConcept C202751555 @default.
- W1967997639 hasConcept C2779814568 @default.
- W1967997639 hasConcept C55493867 @default.
- W1967997639 hasConcept C58943365 @default.
- W1967997639 hasConcept C7070889 @default.
- W1967997639 hasConcept C86803240 @default.
- W1967997639 hasConcept C95444343 @default.
- W1967997639 hasConceptScore W1967997639C106847996 @default.
- W1967997639 hasConceptScore W1967997639C113246987 @default.
- W1967997639 hasConceptScore W1967997639C12554922 @default.
- W1967997639 hasConceptScore W1967997639C1491633281 @default.
- W1967997639 hasConceptScore W1967997639C155672457 @default.
- W1967997639 hasConceptScore W1967997639C171250308 @default.
- W1967997639 hasConceptScore W1967997639C185592680 @default.
- W1967997639 hasConceptScore W1967997639C189165786 @default.
- W1967997639 hasConceptScore W1967997639C192562407 @default.
- W1967997639 hasConceptScore W1967997639C202751555 @default.
- W1967997639 hasConceptScore W1967997639C2779814568 @default.
- W1967997639 hasConceptScore W1967997639C55493867 @default.
- W1967997639 hasConceptScore W1967997639C58943365 @default.
- W1967997639 hasConceptScore W1967997639C7070889 @default.
- W1967997639 hasConceptScore W1967997639C86803240 @default.
- W1967997639 hasConceptScore W1967997639C95444343 @default.
- W1967997639 hasLocation W19679976391 @default.
- W1967997639 hasOpenAccess W1967997639 @default.
- W1967997639 hasPrimaryLocation W19679976391 @default.
- W1967997639 hasRelatedWork W1557457070 @default.
- W1967997639 hasRelatedWork W1978248282 @default.
- W1967997639 hasRelatedWork W1981801486 @default.
- W1967997639 hasRelatedWork W1997323649 @default.
- W1967997639 hasRelatedWork W2015683407 @default.
- W1967997639 hasRelatedWork W2110121410 @default.
- W1967997639 hasRelatedWork W2116328902 @default.
- W1967997639 hasRelatedWork W2160943556 @default.
- W1967997639 hasRelatedWork W2254189772 @default.
- W1967997639 hasRelatedWork W2583463571 @default.
- W1967997639 hasRelatedWork W2745958821 @default.
- W1967997639 hasRelatedWork W275607579 @default.
- W1967997639 hasRelatedWork W2910818397 @default.
- W1967997639 hasRelatedWork W2958424644 @default.
- W1967997639 hasRelatedWork W2985301811 @default.
- W1967997639 hasRelatedWork W3101442571 @default.
- W1967997639 hasRelatedWork W3138667028 @default.
- W1967997639 hasRelatedWork W1511184965 @default.
- W1967997639 hasRelatedWork W1595142685 @default.
- W1967997639 hasRelatedWork W3083520795 @default.
- W1967997639 isParatext "false" @default.
- W1967997639 isRetracted "false" @default.
- W1967997639 magId "1967997639" @default.
- W1967997639 workType "article" @default.