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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1967997906> ?p ?o ?g. }

• W1967997906 endingPage "419" @default.
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• W1967997906 abstract "The function of the CD98hc transmembrane protein in adaptive immune responses has been unclear. Ginsberg and colleagues show that CD98hc is needed for B cell proliferation and subsequent plasma cell differentiation. The proliferation of antigen-specific lymphocytes and resulting clonal expansion are essential for adaptive immunity. We report here that B cell–specific deletion of the heavy chain of CD98 (CD98hc) resulted in lower antibody responses due to total suppression of B cell proliferation and subsequent plasma cell formation. Deletion of CD98hc did not impair early B cell activation but did inhibit later activation of the mitogen-activated protein kinase Erk1/2 and downregulation of the cell cycle inhibitor p27. Reconstitution of CD98hc-deficient B cells with CD98hc mutants showed that the integrin-binding domain of CD98hc was required for B cell proliferation but that the amino acid–transport function of CD98hc was dispensable for this. Thus, CD98hc supports integrin-dependent rapid proliferation of B cells. We propose that the advantage of adaptive immunity favored the appearance of CD98hc in vertebrates." @default.
• W1967997906 created "2016-06-24" @default.
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• W1967997906 date "2009-03-08" @default.
• W1967997906 modified "2023-10-17" @default.
• W1967997906 title "CD98hc facilitates B cell proliferation and adaptive humoral immunity" @default.
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• W1967997906 doi "https://doi.org/10.1038/ni.1712" @default.
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