Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968001556> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1968001556 abstract "Abstract Ehrlich ascites carcinoma cells were cultured in the presence of difluoromethyl ornithine (DFMO) and micromolar concentrations of cadaverine for several months. This treatment resulted in a complete disappearance of putrescine and spermidine and reduced spermine content to traces of its normal content. The natural polyamines were replaced by cadaverine (about 40% of total polyamines), N-(3-aminopropyl)cadaverine (about 50%) and N,N′-bis(3-aminopropyl)cadaverine (about 5%). In comparison with untreated cells or cells grown in the presence of DFMO and putrescine, the “cadaverine cells” grew definitely slower, their protein synthesis was depressed while DNA and RNA syntheses proceeded at near normal rate. In spite of the high intracellular concentrations of cadaverine and its aminopropyl derivatives, the tumor cells grown in the presence of DFMO and cadaverine, behaved exactly like cells severly depleted of putrescine and spermidine. Though exposed to DFMO, ornithine decarboxylase activity was almost 10 times higher than that in untreated cells. S-Adenosyl-L-methionine decarboxylase activity was likewise strikingly elevated, and these cells transported methylglyoxal strikingly elevated, and these cells transported methylglyoxal bis(guanylhydrazone) (MGBG) at a rate that was more than 5 times faster than that in untreated cells. Furthermore, these cells exhibited arginase activity, which was less than one fifth of that found in untreated cells." @default.
- W1968001556 created "2016-06-24" @default.
- W1968001556 creator A5002560406 @default.
- W1968001556 creator A5013639072 @default.
- W1968001556 creator A5067427553 @default.
- W1968001556 creator A5076030656 @default.
- W1968001556 date "1982-05-01" @default.
- W1968001556 modified "2023-09-26" @default.
- W1968001556 title "Replacement of natural polyamines by cadaverine and its aminopropyl derivatives in Ehrlich ascites carcinoma cells" @default.
- W1968001556 cites W1529085592 @default.
- W1968001556 cites W1576879289 @default.
- W1968001556 cites W1775749144 @default.
- W1968001556 cites W1984479924 @default.
- W1968001556 cites W2015923256 @default.
- W1968001556 cites W2018693995 @default.
- W1968001556 cites W2019382570 @default.
- W1968001556 cites W2043816868 @default.
- W1968001556 cites W2045553639 @default.
- W1968001556 cites W2060850029 @default.
- W1968001556 cites W2083786151 @default.
- W1968001556 cites W2092727047 @default.
- W1968001556 cites W2337695169 @default.
- W1968001556 cites W2339893430 @default.
- W1968001556 cites W2340148597 @default.
- W1968001556 cites W2397064475 @default.
- W1968001556 cites W994937244 @default.
- W1968001556 doi "https://doi.org/10.1016/0006-291x(82)91108-1" @default.
- W1968001556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6809002" @default.
- W1968001556 hasPublicationYear "1982" @default.
- W1968001556 type Work @default.
- W1968001556 sameAs 1968001556 @default.
- W1968001556 citedByCount "34" @default.
- W1968001556 crossrefType "journal-article" @default.
- W1968001556 hasAuthorship W1968001556A5002560406 @default.
- W1968001556 hasAuthorship W1968001556A5013639072 @default.
- W1968001556 hasAuthorship W1968001556A5067427553 @default.
- W1968001556 hasAuthorship W1968001556A5076030656 @default.
- W1968001556 hasConcept C121289238 @default.
- W1968001556 hasConcept C153911025 @default.
- W1968001556 hasConcept C181199279 @default.
- W1968001556 hasConcept C185592680 @default.
- W1968001556 hasConcept C202751555 @default.
- W1968001556 hasConcept C2776109719 @default.
- W1968001556 hasConcept C2776197502 @default.
- W1968001556 hasConcept C2776796294 @default.
- W1968001556 hasConcept C2776928777 @default.
- W1968001556 hasConcept C2777167505 @default.
- W1968001556 hasConcept C2777468819 @default.
- W1968001556 hasConcept C2777497464 @default.
- W1968001556 hasConcept C2778592357 @default.
- W1968001556 hasConcept C2780115381 @default.
- W1968001556 hasConcept C2781448169 @default.
- W1968001556 hasConcept C515207424 @default.
- W1968001556 hasConcept C55493867 @default.
- W1968001556 hasConcept C86803240 @default.
- W1968001556 hasConceptScore W1968001556C121289238 @default.
- W1968001556 hasConceptScore W1968001556C153911025 @default.
- W1968001556 hasConceptScore W1968001556C181199279 @default.
- W1968001556 hasConceptScore W1968001556C185592680 @default.
- W1968001556 hasConceptScore W1968001556C202751555 @default.
- W1968001556 hasConceptScore W1968001556C2776109719 @default.
- W1968001556 hasConceptScore W1968001556C2776197502 @default.
- W1968001556 hasConceptScore W1968001556C2776796294 @default.
- W1968001556 hasConceptScore W1968001556C2776928777 @default.
- W1968001556 hasConceptScore W1968001556C2777167505 @default.
- W1968001556 hasConceptScore W1968001556C2777468819 @default.
- W1968001556 hasConceptScore W1968001556C2777497464 @default.
- W1968001556 hasConceptScore W1968001556C2778592357 @default.
- W1968001556 hasConceptScore W1968001556C2780115381 @default.
- W1968001556 hasConceptScore W1968001556C2781448169 @default.
- W1968001556 hasConceptScore W1968001556C515207424 @default.
- W1968001556 hasConceptScore W1968001556C55493867 @default.
- W1968001556 hasConceptScore W1968001556C86803240 @default.
- W1968001556 hasLocation W19680015561 @default.
- W1968001556 hasLocation W19680015562 @default.
- W1968001556 hasOpenAccess W1968001556 @default.
- W1968001556 hasPrimaryLocation W19680015561 @default.
- W1968001556 hasRelatedWork W101226459 @default.
- W1968001556 hasRelatedWork W1606965185 @default.
- W1968001556 hasRelatedWork W1868357828 @default.
- W1968001556 hasRelatedWork W1968001556 @default.
- W1968001556 hasRelatedWork W2018693995 @default.
- W1968001556 hasRelatedWork W2018981379 @default.
- W1968001556 hasRelatedWork W2060591613 @default.
- W1968001556 hasRelatedWork W2082599877 @default.
- W1968001556 hasRelatedWork W2442283683 @default.
- W1968001556 hasRelatedWork W3009448740 @default.
- W1968001556 isParatext "false" @default.
- W1968001556 isRetracted "false" @default.
- W1968001556 magId "1968001556" @default.
- W1968001556 workType "article" @default.