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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968011601> ?p ?o ?g. }

• W1968011601 endingPage "817" @default.
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• W1968011601 abstract "The QSAR directed synthesis of tetracyclic psoralen derivatives (3-5) characterised by the condensation of a cyclopentane ring at the level of the 3,4 double bond of the tricyclic psoralen moiety is reported. The new compounds present a methoxy (3), a hydroxy (4) or a dimethylaminopropoxy (5) side chain inserted in position 8 of the lead chromophore. The evaluation of photoantiproliferative activity on human tumour cell lines reveals for 5 an ability to inhibit cell growth significantly higher with respect to that of the reference drug, 8-MOP. Interestingly, the enhancement in antiproliferative activity is accompanied by the disappearance of skin phototoxicity. On the other hand, no significant photobiological activity was scored for 3 and 4. The ability to photoreact with DNA, evaluated by isolating the 4',5' monoadduct and by estimating the ability to form interstrand cross-links, appeared to be significant for 5, practically negligible for 3 and 4. Furthermore, a back-projection of the more active compound identifies structural features suitable for further synthetic modifications." @default.
• W1968011601 created "2016-06-24" @default.
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• W1968011601 date "2005-02-01" @default.
• W1968011601 modified "2023-10-18" @default.
• W1968011601 title "Design, synthesis and photobiological properties of 3,4-cyclopentenepsoralens" @default.
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• W1968011601 doi "https://doi.org/10.1016/j.bmc.2004.10.044" @default.
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