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- W1968011640 abstract "Abstract The bioavailability of drugs from conventional ophthalmic formulations is low. To optimize the therapy, sustained release ophthalmic dosage forms are warranted. Hydrogels such as sodium-carboxymethyl cellulose, hydroxypropylmethyl cellulose, Carbopol-940, Carbopol-941 and Lutrol-FC-127 increase the duration of action of various drugs. Gels containing pilocarpine were prepared and evaluated by measuring the intensity and duration of miotic response in albino rabbits. Carbopol-940 gels, being the best of those used, were studied further for the effect of its concentration and of additives (benzalkonium chloride, phenylmercuric nitrate, chlorbutol and disodium edetate), autoclaving at 121°C for 30 min and irradiation with gamma rays (2·5 Mrad), on the end product." @default.
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- W1968011640 date "1989-03-01" @default.
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- W1968011640 title "Sustained release ophthalmic formulations of pilocarpine" @default.
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- W1968011640 doi "https://doi.org/10.1111/j.2042-7158.1989.tb06430.x" @default.
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