Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968018974> ?p ?o ?g. }
- W1968018974 endingPage "49" @default.
- W1968018974 startingPage "42" @default.
- W1968018974 abstract "How long organisms live is not entirely written in their genes. Recent findings reveal that epigenetic factors that regulate histone methylation, a type of chromatin modification, can affect lifespan. The reversible nature of chromatin modifications suggests that therapeutic targeting of chromatin regulators could be used to extend lifespan and healthspan. This review describes the epigenetic regulation of lifespan in diverse model organisms, focusing on the role and mode of action of chromatin regulators that affect two epigenetic marks, trimethylated lysine 4 of histone H3 (H3K4me3) and trimethylated lysine 27 of histone H3 (H3K27me3), in longevity. How long organisms live is not entirely written in their genes. Recent findings reveal that epigenetic factors that regulate histone methylation, a type of chromatin modification, can affect lifespan. The reversible nature of chromatin modifications suggests that therapeutic targeting of chromatin regulators could be used to extend lifespan and healthspan. This review describes the epigenetic regulation of lifespan in diverse model organisms, focusing on the role and mode of action of chromatin regulators that affect two epigenetic marks, trimethylated lysine 4 of histone H3 (H3K4me3) and trimethylated lysine 27 of histone H3 (H3K27me3), in longevity." @default.
- W1968018974 created "2016-06-24" @default.
- W1968018974 creator A5074075096 @default.
- W1968018974 creator A5088357328 @default.
- W1968018974 date "2012-01-01" @default.
- W1968018974 modified "2023-10-17" @default.
- W1968018974 title "Histone methylation makes its mark on longevity" @default.
- W1968018974 cites W1481473039 @default.
- W1968018974 cites W1508556872 @default.
- W1968018974 cites W1586705837 @default.
- W1968018974 cites W1658682427 @default.
- W1968018974 cites W1900883967 @default.
- W1968018974 cites W1920889715 @default.
- W1968018974 cites W1963789736 @default.
- W1968018974 cites W1967251674 @default.
- W1968018974 cites W1968880296 @default.
- W1968018974 cites W1968931043 @default.
- W1968018974 cites W1969288350 @default.
- W1968018974 cites W1970338621 @default.
- W1968018974 cites W1972615369 @default.
- W1968018974 cites W1978125302 @default.
- W1968018974 cites W1990396035 @default.
- W1968018974 cites W1992662525 @default.
- W1968018974 cites W1993501399 @default.
- W1968018974 cites W1997353347 @default.
- W1968018974 cites W1999617225 @default.
- W1968018974 cites W2001798854 @default.
- W1968018974 cites W2002741326 @default.
- W1968018974 cites W2004923406 @default.
- W1968018974 cites W2007188652 @default.
- W1968018974 cites W2016024994 @default.
- W1968018974 cites W2017117976 @default.
- W1968018974 cites W2021050536 @default.
- W1968018974 cites W2021856943 @default.
- W1968018974 cites W2022936129 @default.
- W1968018974 cites W2025014803 @default.
- W1968018974 cites W2029073164 @default.
- W1968018974 cites W2030043909 @default.
- W1968018974 cites W2032736838 @default.
- W1968018974 cites W2032859562 @default.
- W1968018974 cites W2033307196 @default.
- W1968018974 cites W2036265947 @default.
- W1968018974 cites W2039196160 @default.
- W1968018974 cites W2046357669 @default.
- W1968018974 cites W2049868369 @default.
- W1968018974 cites W2050314360 @default.
- W1968018974 cites W2052011655 @default.
- W1968018974 cites W2058484936 @default.
- W1968018974 cites W2059255388 @default.
- W1968018974 cites W2063084036 @default.
- W1968018974 cites W2065564965 @default.
- W1968018974 cites W2066186764 @default.
- W1968018974 cites W2072194885 @default.
- W1968018974 cites W2073701988 @default.
- W1968018974 cites W2077612844 @default.
- W1968018974 cites W2078003979 @default.
- W1968018974 cites W2080790343 @default.
- W1968018974 cites W2082396938 @default.
- W1968018974 cites W2084719919 @default.
- W1968018974 cites W2085793595 @default.
- W1968018974 cites W2087214029 @default.
- W1968018974 cites W2089689396 @default.
- W1968018974 cites W2091232875 @default.
- W1968018974 cites W2092015913 @default.
- W1968018974 cites W2093189184 @default.
- W1968018974 cites W2095102047 @default.
- W1968018974 cites W2096011465 @default.
- W1968018974 cites W2096083625 @default.
- W1968018974 cites W2098522762 @default.
- W1968018974 cites W2099008186 @default.
- W1968018974 cites W2101093878 @default.
- W1968018974 cites W2108498698 @default.
- W1968018974 cites W2109027836 @default.
- W1968018974 cites W2109188407 @default.
- W1968018974 cites W2116043907 @default.
- W1968018974 cites W2117224259 @default.
- W1968018974 cites W2117456217 @default.
- W1968018974 cites W2120478300 @default.
- W1968018974 cites W2121945497 @default.
- W1968018974 cites W2125695802 @default.
- W1968018974 cites W2127921893 @default.
- W1968018974 cites W2133452708 @default.
- W1968018974 cites W2137587164 @default.
- W1968018974 cites W2138416557 @default.
- W1968018974 cites W2139384923 @default.
- W1968018974 cites W2148581106 @default.
- W1968018974 cites W2150609732 @default.
- W1968018974 cites W2153478835 @default.
- W1968018974 cites W2154213460 @default.
- W1968018974 cites W2154234231 @default.
- W1968018974 cites W2157649587 @default.
- W1968018974 cites W2159885528 @default.
- W1968018974 cites W2165903668 @default.
- W1968018974 cites W2166037178 @default.
- W1968018974 cites W2170075528 @default.
- W1968018974 cites W2170363318 @default.
- W1968018974 cites W4212766227 @default.
- W1968018974 doi "https://doi.org/10.1016/j.tcb.2011.11.001" @default.