FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1968021269> ?p ?o ?g. }

• W1968021269 endingPage "634" @default.
• W1968021269 startingPage "612" @default.
• W1968021269 abstract "Three-dimensional structures of the transmembrane, seven α-helical domains and extracellular loops of δ, μ, and κ opioid receptors, were calculated using the distance geometry algorithm, with hydrogen bonding constraints based on the previously developed general model of the transmembrane α-bundle for rhodopsin-like G-protein coupled receptors (Biophys. J. 1997. 70:1963). Each calculated opioid receptor structure has an extensive network of interhelical hydrogen bonds and a ligand-binding crevice that is partially covered by a β-hairpin formed by the second extracellular loop. The binding cavities consist of an inner “conserved region” composed of 18 residues that are identical in δ, μ, and κ opioid receptors, and a peripheral “variable region,” composed of 19 residues that are different in δ, μ, and κ subtypes and are responsible for the subtype specificity of various ligands. Sixteen δ-, μ-, or κ-selective, conformationally constrained peptide and nonpeptide opioid agonists and antagonists and affinity labels were fit into the binding pockets of the opioid receptors. All ligands considered have a similar spatial arrangement in the receptors, with the tyramine moiety of alkaloids or Tyr1 of opioid peptides interacting with conserved residues in the bottom of the pocket and the tyramine N+ and OH groups forming ionic interactions or H-bonds with a conserved aspartate from helix III and a conserved histidine from helix VI, respectively. The central, conformationally constrained fragments of the opioids (the disulfide-bridged cycles of the peptides and various ring structures in the nonpeptide ligands) are oriented approximately perpendicular to the tyramine and directed toward the extracellular surface. The results obtained are qualitatively consistent with ligand affinities, cross-linking studies, and mutagenesis data." @default.
• W1968021269 created "2016-06-24" @default.
• W1968021269 creator A5006189599 @default.
• W1968021269 creator A5056114039 @default.
• W1968021269 creator A5079002496 @default.
• W1968021269 date "1998-08-01" @default.
• W1968021269 modified "2023-10-03" @default.
• W1968021269 title "Opioid Receptor Three-Dimensional Structures from Distance Geometry Calculations with Hydrogen Bonding Constraints" @default.
• W1968021269 cites W1445935732 @default.
• W1968021269 cites W1470225921 @default.
• W1968021269 cites W1482251675 @default.
• W1968021269 cites W1544899066 @default.
• W1968021269 cites W1549281008 @default.
• W1968021269 cites W1550501528 @default.
• W1968021269 cites W1581548318 @default.
• W1968021269 cites W1581994435 @default.
• W1968021269 cites W1585778217 @default.
• W1968021269 cites W1590769279 @default.
• W1968021269 cites W1606876786 @default.
• W1968021269 cites W1633206839 @default.
• W1968021269 cites W1686581241 @default.
• W1968021269 cites W1833104430 @default.
• W1968021269 cites W1837577432 @default.
• W1968021269 cites W1843552687 @default.
• W1968021269 cites W1880336884 @default.
• W1968021269 cites W1891097825 @default.
• W1968021269 cites W1919770365 @default.
• W1968021269 cites W1924799369 @default.
• W1968021269 cites W1942766393 @default.
• W1968021269 cites W1960800354 @default.
• W1968021269 cites W1964072615 @default.
• W1968021269 cites W1965469554 @default.
• W1968021269 cites W1966041739 @default.
• W1968021269 cites W1966834056 @default.
• W1968021269 cites W1968269840 @default.
• W1968021269 cites W1970621515 @default.
• W1968021269 cites W1970736360 @default.
• W1968021269 cites W1972500239 @default.
• W1968021269 cites W1973796259 @default.
• W1968021269 cites W1978072288 @default.
• W1968021269 cites W1978886142 @default.
• W1968021269 cites W1980609976 @default.
• W1968021269 cites W1980736544 @default.
• W1968021269 cites W1981493631 @default.
• W1968021269 cites W1982278107 @default.
• W1968021269 cites W1982685951 @default.
• W1968021269 cites W1988074381 @default.
• W1968021269 cites W1988915035 @default.
• W1968021269 cites W1991136759 @default.
• W1968021269 cites W1991953485 @default.
• W1968021269 cites W1994823738 @default.
• W1968021269 cites W1996602924 @default.
• W1968021269 cites W1997502706 @default.
• W1968021269 cites W1998625717 @default.
• W1968021269 cites W2000868201 @default.
• W1968021269 cites W2001051130 @default.
• W1968021269 cites W2001165620 @default.
• W1968021269 cites W2001406669 @default.
• W1968021269 cites W2004811315 @default.
• W1968021269 cites W2006094682 @default.
• W1968021269 cites W2007415752 @default.
• W1968021269 cites W2008867153 @default.
• W1968021269 cites W2011325946 @default.
• W1968021269 cites W2012482043 @default.
• W1968021269 cites W2012638283 @default.
• W1968021269 cites W2013701986 @default.
• W1968021269 cites W2014790390 @default.
• W1968021269 cites W2016275972 @default.
• W1968021269 cites W2018867858 @default.
• W1968021269 cites W2019742616 @default.
• W1968021269 cites W2019958027 @default.
• W1968021269 cites W2022497081 @default.
• W1968021269 cites W2023166473 @default.
• W1968021269 cites W2024505031 @default.
• W1968021269 cites W2025497876 @default.
• W1968021269 cites W2025528306 @default.
• W1968021269 cites W2027977264 @default.
• W1968021269 cites W2029728960 @default.
• W1968021269 cites W2035041777 @default.
• W1968021269 cites W2035077266 @default.
• W1968021269 cites W2035100851 @default.
• W1968021269 cites W2036319515 @default.
• W1968021269 cites W2036379629 @default.
• W1968021269 cites W2037967827 @default.
• W1968021269 cites W2038393008 @default.
• W1968021269 cites W2038748897 @default.
• W1968021269 cites W2041207467 @default.
• W1968021269 cites W2042185302 @default.
• W1968021269 cites W2043429268 @default.
• W1968021269 cites W2043813273 @default.
• W1968021269 cites W2044935190 @default.
• W1968021269 cites W2048046166 @default.
• W1968021269 cites W2050995501 @default.
• W1968021269 cites W2051628563 @default.
• W1968021269 cites W2052142083 @default.
• W1968021269 cites W2053537238 @default.
• W1968021269 cites W2055890854 @default.
• W1968021269 cites W2057491246 @default.

• next